Oleanolic acid can inhibit edema and exhibit obvious inhibitory activity to inflammatory by activating of the pituitary-adrenal cortical system, inhibiting the synthesis or release of PGs, inhibiting endotoxin-mediated release of HMGB1 by endothelial cells or regulating MAPK, PI3K/Akt/NF- κB/ICAM-1/JAK/STAT signaling pathways, etc. In recent years, an increased number of interesting research work has been carried out on the anti-inflammatory activity and mechanisms of OA derivatives, such as acyloxyimino derivative, 3-acetylated derivatives, novel 3,5-disubstituted isoxazoles derivatives, acetate, ester derivatives and oximes derivatives. The review summaries and highlights the updated advances on the anti-inflammatory activity and mechanism of OA and its derivatives.

齐墩果酸可通过激活垂体-肾上腺皮质系统，抑制PGs的合成或释放，抑制内毒素介导的内皮细胞释放HMGB1或调节MAPK、PI3K/Akt/NF- κB/ICAM-1/JAK/STAT 信号通路等。近年来，越来越多的有趣的研究工作在 OA 衍生物，如酰氧基亚氨基衍生物、3-乙酰化衍生物的抗炎活性和机制方面开展。 , 新型 3,5-二取代异恶唑衍生物、乙酸酯、酯衍生物和肟衍生物。该综述总结并强调了 OA 及其衍生物抗炎活性和机制的最新进展。