In this article, we argue that stigma may be an important, but heretofore underrecognized, source of heterogeneity in treatment effects of mental- and behavioral-health interventions. To support this hypothesis, we review recent evidence from randomized controlled trials and spatial meta-analyses suggesting that stigma may predict not only who responds more favorably to these health interventions (i.e., individuals with more stigma experiences), but also the social contexts that are more likely to undermine intervention effects (i.e., communities with greater structural stigma). By highlighting the potential role of personal and contextual stigma in shaping response to interventions, our review paves the way for additional research.

在本文中，我们认为污名可能是心理和行为健康干预治疗效果异质性的一个重要来源，但迄今为止尚未得到充分认识。为了支持这一假设，我们回顾了来自随机对照试验和空间荟萃分析的最新证据，这些证据表明，污名不仅可以预测谁对这些健康干预措施的反应更有利（即具有更多污名经历的个人），还可以预测产生更有可能破坏干预效果（即具有更大结构性污名的社区）。通过强调个人​​和背景耻辱在塑造对干预措施的反应方面的潜在作用，我们的审查为进一步研究铺平了道路。