Metal-free electrochemical synthesis of α-ketoamides via decarboxylative coupling of α-keto acids with isocyanides and water,Organic Chemistry Frontiers

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Metal-free electrochemical synthesis of α-ketoamides via decarboxylative coupling of α-keto acids with isocyanides and water
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2021-10-26 , DOI: 10.1039/d1qo01351c
Feng Zhao ₁ , Na Meng ₂ , Ting Sun ₁ , Jiangwei Wen ₂ , Xiaohui Zhao ₃ , Wei Wei _{2,

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Affiliation

A mild and environmentally benign electrochemical strategy has been developed for the synthesis of α-ketoamides via a decarboxylative coupling reaction of α-keto acids with isocyanides and water. The present reaction was efficiently conducted under constant current electrolysis using n-Bu₄NI as the electrolyte in an undivided cell. A series of α-ketoamides could be conveniently and rapidly constructed at room temperature in the absence of transition metal catalysts and external oxidants. Mechanistic studies suggested that water not only served as a starting material to construct α-ketoamides, but also played an important role in promoting the electrochemical redox of α-keto acids.

中文翻译：

通过α-酮酸与异氰化物和水的脱羧偶联无金属电化学合成α-酮酰胺

通过α-酮酸与异氰化物和水的脱羧偶联反应，已经开发出一种温和且环境友好的电化学策略，用于合成α-酮酰胺。本反应在恒流电解下有效地进行，使用n -Bu ₄ NI 作为未分隔电池中的电解质。在没有过渡金属催化剂和外部氧化剂的情况下，可以在室温下方便、快速地构建一系列α-酮酰胺。机理研究表明，水不仅可以作为构建 α-酮酰胺的起始材料，而且在促进 α-酮酸的电化学氧化还原方面也发挥了重要作用。

更新日期：2021-11-08

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