The Human Plasma Proteome has always been the most investigated compartment in proteomics-based biomarker discovery, and is considered the largest and deepest version of the human proteome, reflecting the state of the body in health and disease. Even if efforts have been always dedicated to the refinement of proteomic approaches to investigate more deeply the plasma proteome, it should not be forgotten that also highly abundant plasma proteins, like human serum albumin (HSA), often neglected in these studies, might provide fundamental physiological functions in plasma, and should be better considered. This review summarizes the important roles of HSA in the context of cardiovascular diseases (CVD), and in particular in heart failure. Notwithstanding much attention has been historically directed toward the association of HSA levels and CVD risk, the advances in the field of mass spectrometry research allow also a better characterization of the effects of oxidative modifications that could alter not only the structure but also the function of HSA.

中文翻译：

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关于白蛋白在心血管疾病中的新见解：关注心力衰竭

人类血浆蛋白质组一直是基于蛋白质组学的生物标志物发现中研究最多的部分，被认为是人类蛋白质组的最大和最深版本，反映了身体在健康和疾病中的状态。即使一直致力于改进蛋白质组学方法以更深入地研究血浆蛋白质组，也不应忘记，在这些研究中经常被忽视的高丰度血浆蛋白，如人血清白蛋白 (HSA)，可能提供基础血浆中的生理功能，应该更好地考虑。本综述总结了 HSA 在心血管疾病 (CVD) 中的重要作用，尤其是在心力衰竭中。尽管历史上很多注意力都集中在 HSA 水平和 CVD 风险的关联上，