As reported recently in Science Translational Medicine, intra-tumoral administration of mRNAs that encode four cytokines formulated in saline mediates regression of injected and distant murine tumors. The anti-tumor effect, which is also seen in the anti-PD-1-resistant setting and enhanced by checkpoint blockade, is mediated by tumor-specific T cells and natural killer cells.

中文翻译：

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利用信使：具有全身效应的 RNA 肿瘤内递送

正如最近在《科学转化医学》中报道的那样，肿瘤内施用编码四种在盐水中配制的细胞因子的 mRNA 可介导注射和远处鼠类肿瘤的消退。抗肿瘤作用也见于抗 PD-1 耐药环境，并通过检查点阻断增强，由肿瘤特异性 T 细胞和自然杀伤细胞介导。