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T cell engagers in solid tumors kick the door down
Cancer Cell ( IF 48.8 ) Pub Date : 2021-11-08 , DOI: 10.1016/j.ccell.2021.10.005
Maria de Miguel 1 , Emiliano Calvo 1
Affiliation  

Tebentafusp, a T cell-redirecting, bispecific-antibody-targeting, HLA02:01-restricted gp100 peptide and CD3, induces T cells to kill glycoprotein 100 (gp100)-expressing tumor cells. Tebentafusp is the first T cell engager to show a statistically significant overall survival improvement for the treatment of patients with solid tumors, and this has been reported in the New England Journal of Medicine.



中文翻译:

实体瘤中的 T 细胞参与者敲门

Tebentafusp 是一种 T 细胞重定向、双特异性抗体靶向、HLA * 02:01限制性 gp100 肽和 CD3,可诱导 T 细胞杀死表达糖蛋白 100 (gp100) 的肿瘤细胞。Tebentafusp 是第一个在实体瘤患者的治疗中显示出统计学上显着的总体生存改善的 T 细胞接合剂,这已在新英格兰医学杂志上进行了报道。

更新日期:2021-11-08
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