Metal- and Solvent-Free Cascade Reaction for the Synthesis of Amino Pyrazole Thioether Derivatives,The Journal of Organic Chemistry

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Metal- and Solvent-Free Cascade Reaction for the Synthesis of Amino Pyrazole Thioether Derivatives
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2021-11-08 , DOI: 10.1021/acs.joc.1c01846
Sesuraj Babiola Annes ₁ , Rajendhiran Saritha ₁ , Kuppusamy Chandru ₁ , Pavan Kumar Mandali ₁ , Subburethinam Ramesh ₁

Affiliation

We developed an iodine-mediated cascade strategy to synthesize amino pyrazole thioether derivatives (11) in the absence of metals as well as solvents. The present approach provides amino pyrazole thioethers in a highly selective manner without the formation of diaryl sulfide and sulfenyl-enaminonitrile with broad substrate scope. The reactivity of nine sulfenylation sources and synthetic applications of the synthesized compounds have been demonstrated. Thus, the overall iodine-mediated multicomponent reaction (MCR) is more economically feasible, efficient, and environmentally benign.

中文翻译：

用于合成氨基吡唑硫醚衍生物的无金属和无溶剂级联反应

我们开发了一种碘介导的级联策略，在没有金属和溶剂的情况下合成氨基吡唑硫醚衍生物 ( 11 )。本方法以高度选择性的方式提供氨基吡唑硫醚，而不会形成具有广泛底物范围的二芳基硫醚和亚磺基-烯氨基腈。已经证明了九种亚磺酰化源的反应性和合成化合物的合成应用。因此，整体碘介导的多组分反应 (MCR) 在经济上更可行、更有效且对环境无害。

更新日期：2021-12-03

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