In 2021, our understanding of resistance to therapy in primary liver tumours improved drastically. By taking a holistic approach, three independent studies have characterized the tumour cell biodiversity across space, time and aetiologies in primary liver cancer, decoding the crosstalk between different cell types within the tumour ecosystem and their individual contributions to therapy resistance.

中文翻译：

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解码肝脏肿瘤的治疗耐药性：一个巨大的飞跃

2021 年，我们对原发性肝肿瘤治疗耐药性的理解有了显着提高。通过采用整体方法，三项独立研究表征了原发性肝癌中跨空间、时间和病因的肿瘤细胞生物多样性，解码了肿瘤生态系统内不同细胞类型之间的串扰及其对治疗抵抗的个体贡献。