Solubility Measurement of Tiopronin in Four Mixed Solvents at 273.15–318.15 K and Correlation Using Thermodynamic Models,Journal of Chemical & Engineering Data

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Solubility Measurement of Tiopronin in Four Mixed Solvents at 273.15–318.15 K and Correlation Using Thermodynamic Models
Journal of Chemical & Engineering Data ( IF 2.0 ) Pub Date : 2021-11-08 , DOI: 10.1021/acs.jced.1c00505
Shasha Li _{1,

2} , Xin Zhuo _{1,

2,

3} , Xue Gao _{1,

2,

3}

Affiliation

The solubility data of tiopronin in four binary mixtures in the temperature range from 273.15 to 318.15 K were obtained using the isothermal saturation method under 101.3 kPa. In mixtures of 1-butanol + toluene and 1-butanol + acetonitrile, the mole solubility data increased monotonically with the increasing mass fraction of 1-butanol at a certain temperature. In addition, it increased to the maximum and then decreased with the increasing mass fraction of i-butanol in systems of i-butanol + toluene and i-butanol + acetonitrile. The maximum values in mixtures of 1-butanol + toluene and 1-butanol + acetonitrile were all obtained in pure 1-butanol (0.103 at 318.15 K), while these data in systems of i-butanol + toluene and i-butanol + acetonitrile were 4.644 × 10^–2 and 5.243 × 10^–2 at 318.15 K, respectively. The solubility data were correlated using the Jouyban–Acree model and CNIBS/R–K model. The maximum relative average deviation value was no more than 5%. In addition, the square of the linear correlation coefficient between experimental and calculated values is closer to 1. Therefore, the Jouyban–Acree model is suitable to correlate the solubility values of tiopronin in selected binary mixtures at studied temperatures. The solubility data and model parameters were important for the preparation and purification of tiopronin.

中文翻译：

硫普罗宁在 273.15-318.15 K 的四种混合溶剂中的溶解度测量以及使用热力学模型的相关性

采用等温饱和法在101.3 kPa下得到硫普罗宁在273.15～318.15 K温度范围内的四种二元混合物中的溶解度数据。在 1-丁醇 + 甲苯和 1-丁醇 + 乙腈的混合物中，摩尔溶解度数据在一定温度下随着 1-丁醇质量分数的增加而单调增加。此外，在异丁醇+甲苯和异丁醇+乙腈体系中，随着异丁醇质量分数的增加，它增加到最大值然后减小。1-丁醇 + 甲苯和 1-丁醇 + 乙腈混合物的最大值都是在纯 1-丁醇中获得的（在 318.15 K 时为 0.103），而这些数据在异丁醇 + 甲苯和i-丁醇 + 乙腈在 318.15 K 时分别为 4.644 × 10 ^–2和 5.243 × 10 ^–2。溶解度数据使用 Jouyban-Acree 模型和 CNIBS/R-K 模型相关联。最大相对平均偏差值不超过5%。此外，实验值和计算值之间的线性相关系数的平方接近 1。因此，Jouyban-Acree 模型适用于关联硫普罗宁在所选二元混合物中在研究温度下的溶解度值。溶解度数据和模型参数对于硫普罗宁的制备和纯化很重要。

更新日期：2021-12-09

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