A relatively small number of drugs have been responsible for major advances in medical practice. The discovery, development, and elucidation of the mechanisms of action of aspirin, penicillin, and statins are remarkable success stories, each with some surprises and each crowned by a Nobel Prize. The sodium glucose co-transporter inhibitors have been proven effective in the treatment of type 2 diabetes mellitus, various forms of heart failure, and kidney failure and represent the, or one of the, major pharmacological advances in cardiovascular medicine in the 21st century.

中文翻译：

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SGLT2 抑制剂：21 世纪的他汀类药物

相对较少的药物对医疗实践的重大进步负有责任。阿司匹林、青霉素和他汀类药物作用机制的发现、开发和阐明是非凡的成功故事，每一个都带来了一些惊喜，每一个都获得了诺贝尔奖。钠葡萄糖协同转运蛋白抑制剂已被证明可有效治疗 2 型糖尿病、各种形式的心力衰竭和肾衰竭，代表了 21 世纪心血管医学的主要药理学进展或其中之一。