Iron-Catalyzed Alkene Trifluoromethylation in Tandem with Phenol Dearomatizing Spirocyclization: Regioselective Construction of Trifluoromethylated Spirocarbocycles,Advanced Synthesis & Catalysis

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Iron-Catalyzed Alkene Trifluoromethylation in Tandem with Phenol Dearomatizing Spirocyclization: Regioselective Construction of Trifluoromethylated Spirocarbocycles
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2021-11-05 , DOI: 10.1002/adsc.202101201
Yilin Zhao ₁ , Xue Wang ₁ , Ru Yao ₁ , Chengwen Li ₁ , Zelin Xu ₁ , Liming Zhang ₁ , Guifang Han ₂ , Jingli Hou ₂ , Yangping Liu ₁ , Yuguang Song ₂

Affiliation

In the presence of Fe(III) complex and Bipy ligand, CF₃-containing spirocarbocycles were conveniently obtained in 20–99% yields with high regioselectivity through Iron-catalyzed trifluoromethylation of unactivated alkenes coupled with phenol dearomatizing spirocyclization.

中文翻译：