Long-term rhythm monitoring (LTRM) can detect undiagnosed atrial fibrillation (AF) in patients at high risk of AF and stroke. Biomarkers and echocardiographic parameters could, however, help identify patients benefitting most from LTRM. The aim of this study was to investigate, whether circulating biomarkers of cardiac and vascular function (brain natriuretic peptide (BNP), cardiac troponin I (cTnI), copeptin, and mid-regional proadrenomedullin (MR-proADM)) and echocardiographic parameters were associated with incident subclinical AF (SCAF) in a population at high risk of stroke in the presence of AF. For this purpose, we investigated individuals ≥65 years of age with hypertension and diabetes mellitus, but no history or symptoms of AF or other cardiovascular disease (CVD).

中文翻译：

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糖尿病和高血压患者的循环生物标志物、超声心动图参数和亚临床房颤事件

长期节律监测 (LTRM) 可以检测高风险 AF 和中风患者的未确诊心房颤动 (AF)。然而，生物标志物和超声心动图参数可以帮助识别从 LTRM 中获益最多的患者。本研究的目的是调查心脏和血管功能的循环生物标志物（脑利钠肽 (BNP)、心肌肌钙蛋白 I (cTnI)、和肽素和中区肾上腺髓质素原 (MR-proADM)）是否与超声心动图参数相关在存在 AF 的高卒中风险人群中发生亚临床 AF (SCAF)。为此，我们调查了≥65 岁的高血压和糖尿病患者，但没有 AF 或其他心血管疾病 (CVD) 的病史或症状。