Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the most common tumors in women worldwide. To date, no long-term or non-invasive treatment option exists for hormone-dependent uterine fibroids due to the limited knowledge about the molecular mechanisms underlying the initiation and development of uterine fibroids. This paper comprehensively summarizes the recent research advances on uterine fibroids, focusing on their risk factors, development origin, pathogenetic mechanisms, and treatment options. Additionally, we describe the current treatment interventions for uterine fibroids. Finally, future perspectives on uterine fibroids studies are summarized. Deeper mechanistic insights into tumor etiology and uterine fibroids’ complexity can contribute to the newer targeted therapies.

中文翻译：

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子宫肌瘤的综合回顾：发育起源、发病机制和治疗

子宫肌瘤是子宫肌层的良性单克隆肿瘤，是全世界女性最常见的肿瘤。迄今为止，由于对子宫肌瘤发生和发展的分子机制的了解有限，激素依赖性子宫肌瘤尚无长期或非侵入性治疗选择。本文就子宫肌瘤的危险因素、发展起源、发病机制和治疗方案等方面，全面总结了近年来子宫肌瘤的研究进展。此外，我们描述了目前子宫肌瘤的治疗干预措施。最后，总结了子宫肌瘤研究的未来前景。对肿瘤病因学和子宫肌瘤复杂性的更深入的机制洞察可以促进更新的靶向治疗。