Background

To explore the research trends for uveal melanoma with bibliometric methods using Web of Science Core Collection (WoSCC) and PubMed (PM).

Methods

To find UM-related studies, “uveal melanoma” was used as search term in the WoSCC and PM for the period time from 2000 to 2020. Bibliographic coupling analysis was used to investigate the journals with the highest number of UM-related publications. VOSviewer (VV) was used for mapping the knowledge domain and visualizing the co-occurrence of terms, authors, organizations, countries, co-citation literature, and keywords. The knowledge map based on WoSCC and PM was compared.

Results

In the WoSCC 3,748 articles were found, while in PM the search resulted in 3,403 articles. The number of original articles has steadily grown in general in the past two decades. The top ten authors were contributing to 23% (n = 856) of all publications, while the top 10 institutions published 41% (n = 1524) of all articles. The top 3 journals with the highest number of publications for UM-related research included Investigative ophthalmology & visual science, Ophthalmology, and British Journal of Ophthalmology. Co-occurrence analysis based on author keywords showed 6 clusters. The most frequent keywords included are metastasis, prognosis, and brachytherapy. The latest research hotspots focused on BAP1, immunotherapy and GNAQ.

Conclusions

Genetics and immunology are the latest research frontiers in uveal melanoma. There is a clear need for interdisciplinary, molecular and clinical research approaches to improve the fatal prognosis of uveal melanoma patients.

中文翻译：

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绘制葡萄膜黑色素瘤的研究趋势：文献计量分析

背景

利用 Web of Science 核心合集 (WoSCC) 和 PubMed (PM) 的文献计量方法探索葡萄膜黑色素瘤的研究趋势。

方法

为了查找与 UM 相关的研究，“葡萄膜黑色素瘤”被用作 2000 年至 2020 年期间 WoSCC 和 PM 中的搜索词。书目耦合分析用于调查与 UM 相关出版物数量最多的期刊。VOSviewer (VV) 用于映射知识领域，并可视化术语、作者、组织、国家、共引文献和关键字的共现。比较了基于WoSCC和PM的知识图谱。

结果

在 WoSCC 中找到了 3,748 篇文章，而在 PM 中搜索到了 3,403 篇文章。在过去的二十年中，原创文章的数量总体上稳步增长。前 10 位作者贡献了所有出版物的 23% ( n  = 856)，而排名前 10 位的机构发表了所有文章的 41% ( n  = 1524)。UM 相关研究出版物数量最多的前 3 位期刊包括Investigative ophthalmology & visual science、Ophthalmology和British Journal of Ophthalmology。基于作者关键词的共现分析显示 6 个聚类。最常见的关键词是转移、预后和近距离放射治疗。最新研究热点集中在BAP1、免疫治疗和GNAQ。

结论

遗传学和免疫学是葡萄膜黑色素瘤的最新研究前沿。显然需要跨学科、分子和临床研究方法来改善葡萄膜黑色素瘤患者的致命预后。