Introduction

Pseudoexfoliation syndrome (PES) is an age-related process associated with glaucoma and cataracts. It increases the risk of complications during cataract surgery. Blood neutrophil-to-lymphocyte ratio (NLR) is shown to be an effective biomarker of inflammation in PES. We aimed to investigate association of NLR and pseudoexfoliation (PEX) related cataract surgery complications.

Methods

A total of 210 eyes who underwent cataract surgery between January 2016 and January 2020 in our department were analyzed retrospectively. Patients were grouped with respect to developing complications and the two groups were compared. Medical records were reached to obtain neutrophil and lymphocyte values to calculate NLR. Data obtained were analyzed using chi-square test. Receiver operating characteristics curve analysis was performed to determine cutoff, sensitivity and specificity values. p value of ≤ 0.05 was considered statistically significant.

Results

The mean age was 68.1 ± 7.2 years and mean NLR was 2.11 ± 0.81. Complications were observed in 32 (15.2%) of the patients (group 1). Neutrophil counts (5.19 ± 0.64 vs. 4.43 ± 0.86, p < 0.001) and the NLR (2.68 ± 0.73 vs. 2.01 ± 0.81, p < 0.001) of group 1 were significantly higher than group 2. The ROC analysis revealed a cutoff value of 2.33 for NLR to predict cataract surgery complications with sensitivity of 87.5% and specificity of 78.1%.

Conclusion

There is an association between NLR and increased risk of complications during cataract surgery in PES patients. NLR can be used as an easy method to help ophthalmologists in predicting the risks associated with cataract surgery in PEX eyes.

中文翻译：

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中性粒细胞淋巴细胞比值作为 PEX 综合征患者白内障手术期间围手术期并发症的预测指标

介绍

假性剥脱综合征 (PES) 是与青光眼和白内障相关的年龄相关过程。它增加了白内障手术期间并发症的风险。血液中性粒细胞与淋巴细胞的比率 (NLR) 被证明是 PES 炎症的有效生物标志物。我们旨在调查 NLR 和假性剥脱 (PEX) 相关白内障手术并发症的关联。

方法

回顾性分析2016年1月至2020年1月在我科接受白内障手术的210只眼。患者根据出现的并发症进行分组，并对两组进行比较。达到医疗记录以获得中性粒细胞和淋巴细胞值以计算NLR。使用卡方检验分析获得的数据。进行接受者操作特征曲线分析以确定临界值、敏感性和特异性值。p值≤0.05被认为具有统计学意义。

结果

平均年龄为 68.1 ± 7.2 岁，平均 NLR 为 2.11 ± 0.81。32 名（15.2%）患者（第 1 组）出现并发症。第 1 组的中性粒细胞计数 (5.19 ± 0.64 vs. 4.43 ± 0.86, p  < 0.001) 和 NLR (2.68 ± 0.73 vs. 2.01 ± 0.81, p  < 0.001) 显着高于组 2。ROC 分析显示截止值NLR 预测白内障手术并发症的敏感性为 2.33，敏感性为 87.5%，特异性为 78.1%。

结论

NLR 与 PES 患者白内障手术期间并发症风险增加之间存在关联。NLR 可以作为一种简单的方法来帮助眼科医生预测与 PEX 眼白内障手术相关的风险。