Purpose

To describe the pattern of quantitative parasympathetic cardiovascular autonomic function among patients with normal-tension glaucoma (NTG) and high-tension primary open-angle glaucoma (HTG) patients.

Methodology

This was cross-sectional study of ninety-two subjects enrolled into three groups: HTG (31 patients), NTG (31 patients) and Control (30 patients). All the participants had anthropometric assessment, ophthalmic examination, baseline cardiovascular examination and the three parasympathetic components of Ewing’s battery of autonomic cardiovascular function tests namely heart rate (HR) response to deep breathing, HR response to Valsalva manoeuvre and HR response to standing.

Result

The baseline PR intervals were significantly prolonged in HTG (0.18 ± 0.03 s) and NTG (0.18 ± 0.04 s) groups compared with control (0.15 ± 0.03 s) (p = 0.008). The HTG group had a significantly longer mean RR interval (1.09 ± 0.17 s) than the NTG group (1.03 ± 0.20 s) and control (0.97 ± 0.17 s) during the expiratory phase of the HR response to deep breathing test (p = 0.037). The HTG group also had significantly longer mean RR intervals around the 15th beat (p = 0.033) and 30th beats (p = 0.202) post-standing during the HR response to standing test. The HR response to Valsalva manoeuvre test showed a significantly higher mean Valsalva ratio in the NTG group (1.65 ± 0.48) compared to the HTG group (1.45 ± 0.31) and control (1.43 ± 0.25) (p = 0.034).

Conclusion

This study demonstrated that normal-tension and high-tension primary open-angle glaucoma have higher parasympathetic cardiovascular activity than normal individuals.

中文翻译：

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原发性开角型青光眼副交感神经心血管活动的评估

目的

描述正常眼压青光眼 (NTG) 和高眼压原发性开角型青光眼 (HTG) 患者的定量副交感神经心血管自主神经功能模式。

方法

这是纳入三组的九十二名受试者的横断面研究：HTG（31 名患者）、NTG（31 名患者）和对照组（30 名患者）。所有参与者都进行了人体测量学评估、眼科检查、基线心血管检查和尤因自主心血管功能测试的三个副交感神经成分，即对深呼吸的心率 (HR) 反应、对 Valsalva 动作的 HR 反应和对站立的 HR 反应。

结果

与对照组 (0.15 ± 0.03 s) 相比，HTG (0.18 ± 0.03 s) 和 NTG (0.18 ± 0.04 s) 组的基线 PR 间期显着延长 ( p  = 0.008)。在 HR 响应深呼吸测试的呼气阶段，HTG 组的平均 RR 间期（1.09 ± 0.17 s）明显长于 NTG 组（1.03 ± 0.20 s）和对照组（0.97 ± 0.17 s）（p  = 0.037 ）。HTG 组在第 15 次心跳 ( p  = 0.033) 和第 30 次心跳 ( p = 0.202) 在 HR 对站立测试的反应期间站立后。与 HTG 组 (1.45 ± 0.31) 和对照组 (1.43 ± 0.25) 相比，NTG 组 (1.65 ± 0.48) 对 Valsalva 动作测试的 HR 反应显示出显着更高的平均 Valsalva 比 ( p  = 0.034)。

结论

该研究表明，正常眼压和高眼压原发性开角型青光眼比正常人具有更高的副交感神经心血管活动。