How somatic and germline mutations interact in cancer remains largely unexplored. A study of 17,152 patients with cancer suggests that the relative contribution of pathogenic germline mutations is governed by lineage and penetrance.

中文翻译：

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种系如何影响体细胞景观

体细胞和种系突变如何在癌症中相互作用在很大程度上仍未被探索。一项对 17,152 名癌症患者的研究表明，致病性种系突变的相对贡献受谱系和外显率控制。