Chronic wasting disease (WD) is a fatal prion disease of cervids. We examined host range of CWD by oronasally inoculating Suffolk sheep with brain homogenate from a CWD-positive white-tailed deer. Sixty months after inoculation, 1/7 sheep had immunoreactivity against the misfolded form of prion protein in lymphoid tissue. Results were confirmed by mouse bioassay.

中文翻译：

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慢性消耗性疾病病原体从白尾鹿到萨福克绵羊的实验性口鼻传播

慢性消耗性疾病 (WD) 是鹿科动物的一种致命的朊病毒病。我们通过用来自 CWD 阳性白尾鹿的脑匀浆口鼻接种萨福克绵羊来检查 CWD 的宿主范围。接种 60 个月后，1/7 绵羊对淋巴组织中错误折叠的朊病毒蛋白具有免疫反应性。结果由小鼠生物测定证实。