Background/aims To identify clinical characteristics and factors associated with microcystic macular edema (MME) in patients with primary open-angle glaucoma (POAG). Methods We included 315 POAG eyes between 2010 and 2019 with good-quality macular volume scans that had reliable visual fields (VF) available within 6 months in this observational retrospective cohort study. Eyes with retinal pathologies except for epiretinal membrane (ERM) were excluded. The inner nuclear layer was qualitatively assessed for the presence of MME. Global mean deviation (MD) and Visual Field Index (VFI) decay rates, superior and inferior MD rates and pointwise total deviation rates of change were estimated with linear regression. Logistic regression was performed to identify baseline factors associated with the presence of MME and to determine whether MME is associated with progressive VF loss. Results 25 out of 315 eyes (7.9%) demonstrated MME. The average (±SD) age and MD in eyes with and without MME was 57.2 (±8.7) versus 62.0 (±9.9) years (p=0.02) and −9.8 (±5.7) versus −4.9 (±5.3) dB (p<0.001), respectively. Worse global MD at baseline (p=0.001) and younger age (p=0.02) were associated with presence of MME. ERM was not associated with the presence of MME (p=0.84) in this cohort. MME was not associated with MD and VFI decay rates (p>0.49). Conclusions More severe glaucoma and younger age were associated with MME. MME was not associated with faster global VF decay in this cohort. MME may confound monitoring of glaucoma with full macular thickness. Data are available upon reasonable request. Data is deidentified participant data and can be requested from glaucoma@jsei.ucla.edu. Reasonable requests include similar or related analyses.

中文翻译：

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青光眼黄斑微囊水肿的危险因素


背景/目的 确定原发性开角型青光眼 (POAG) 患者的临床特征和与微囊性黄斑水肿 (MME) 相关的因素。方法 在这项观察性回顾性队列研究中，我们纳入了 2010 年至 2019 年间的 315 只 POAG 眼，这些眼进行了高质量的黄斑容积扫描，这些扫描在 6 个月内提供了可靠的视野 (VF)。排除除视网膜前膜（ERM）之外的视网膜病变的眼睛。对内核层 MME 的存在进行定性评估。通过线性回归估计全局平均偏差 (MD) 和视野指数 (VFI) 衰减率、上、下 MD 率以及逐点总偏差变化率。进行逻辑回归以确定与 MME 存在相关的基线因素，并确定 MME 是否与进行性 VF 丧失相关。结果 315 只眼睛中有 25 只眼睛 (7.9%) 表现出 MME。患有和不患有 MME 的眼睛的平均 (±SD) 年龄和 MD 分别为 57.2 (±8.7) 岁与 62.0 (±9.9) 岁 (p=0.02) 以及 -9.8 (±5.7) 与 -4.9 (±5.3) dB (p <0 id=21>0.49）。结论 更严重的青光眼和更年轻的年龄与 MME 相关。 MME 与该队列中更快的整体 VF 衰减无关。 MME 可能会混淆青光眼与全黄斑厚度的监测。数据可根据合理要求提供。数据是去识别化的参与者数据，可以通过 glaucoma@jsei.ucla.edu 索取。合理的请求包括类似或相关的分析。