Air pollution particulate matter (PM) is associated with SARS-CoV-2 infection and severity, although mechanistic studies are lacking. We tested whether airway surface liquid (ASL) from primary human airway epithelial cells is antiviral against SARS-CoV-2 and human alphacoronavirus 229E (CoV-229E) (responsible for common colds), and whether PM (urban, indoor air pollution [IAP], volcanic ash) affected ASL antiviral activity. ASL inactivated SARS-CoV-2 and CoV-229E. Independently, urban PM also decreased SARS-CoV-2 and CoV-229E infection, and IAP PM decreased CoV-229E infection. However, in combination, urban PM impaired ASL’s antiviral activity against both viruses, and the same effect occurred for IAP PM and ash against SARS-CoV-2, suggesting that PM may enhance SARS-CoV-2 infection.

中文翻译：

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城市颗粒物对气道表面的损害液体介导的冠状病毒灭活


尽管缺乏机制研究，但空气污染颗粒物 (PM) 与 SARS-CoV-2 感染及其严重程度相关。我们测试了来自人原代气道上皮细胞的气道表面液体 (ASL) 是否具有针对 SARS-CoV-2 和人类 α 冠状病毒 229E (CoV-229E)（导致普通感冒）的抗病毒作用，以及 PM（城市室内空气污染 [IAP]）是否具有抗病毒作用。 ]、火山灰）影响了 ASL 的抗病毒活性。 ASL 灭活了 SARS-CoV-2 和 CoV-229E。独立地，城市 PM 还减少了 SARS-CoV-2 和 CoV-229E 感染，IAP PM 减少了 CoV-229E 感染。然而，综合起来，城市 PM 损害了 ASL 对两种病毒的抗病毒活性，IAP PM 和灰烬对 SARS-CoV-2 也产生了相同的效果，表明 PM 可能会增强 SARS-CoV-2 感染。