Update on the Synthesis of N-Heterocycles via Cyclization of Hydrazones (2017–2021),Advanced Synthesis & Catalysis

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Update on the Synthesis of N-Heterocycles via Cyclization of Hydrazones (2017–2021)
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2021-11-03 , DOI: 10.1002/adsc.202101184
Yunhe Lv ₁ , Jianping Meng ₂ , Chen Li ₂ , Wang Xin ₃ , Yong Ye ₄ , Kai Sun ₁

Affiliation

Hydrazones, as universal structural units, are useful synthons for the formation of carbon–nitrogen and nitrogen−heteroatom bonds. Thus, they provide new methods of constructing nitrogen-containing heterocycles. In recent years, especially between 2017 and 2021, many efforts have been made to exploit hydrazone-based reactions in efforts to develop more powerful and effective pathways towards the synthesis of various multifunctional heterocyclic compounds. However, despite the tremendous amount of work that has been published over the past five years, no review has been published that summarizes the significant progress in the preparation of nitrogen heterocycles via intramolecular cyclization of hydrazones with adjacent unsaturated bonds or intermolecular cyclization of hydrazones with unsaturated systems. Therefore, this review summarizes the hydrazone-based cyclization strategies used to synthesize nitrogen-containing heterocycles over the past five years. It discusses the corresponding reaction scopes, limitations, mechanisms, and problems.

中文翻译：

通过腙环化合成 N-杂环的更新（2017-2021）

腙作为通用结构单元，是形成碳-氮和氮-杂原子键的有用合成子。因此，它们提供了构建含氮杂环的新方法。近年来，尤其是 2017 年至 2021 年间，已经做出了许多努力来利用腙基反应，努力开发更强大、更有效的合成各种多功能杂环化合物的途径。然而，尽管在过去五年中发表了大量的工作，但还没有发表综述总结通过腙与相邻不饱和键的分子内环化或腙与不饱和键的分子间环化制备氮杂环的重大进展。系统。所以，本综述总结了过去五年中用于合成含氮杂环的基于腙的环化策略。它讨论了相应的反应范围、局限性、机制和问题。

更新日期：2021-12-07

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