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Avoid shocking your hematopoietic stem cells to keep them young and growing
Cell Stem Cell ( IF 19.8 ) Pub Date : 2021-11-04 , DOI: 10.1016/j.stem.2021.10.007
Maria-Eleni Lalioti 1 , Jasmin Rettkowski 1 , Nina Cabezas-Wallscheid 2
Affiliation  

Expanding hematopoietic stem cells (HSCs) ex vivo has historically been a very challenging process. In this issue of Cell Stem Cell, Kruta et al. (2021) identify heat shock factor 1 (Hsf1) as a new target to maintain HSC fitness and protein homeostasis, not only in culture conditions but also upon aging.



中文翻译:

避免电击您的造血干细胞,让它们保持年轻和成长

扩增造血干细胞(HSCs)体外历来一个非常具有挑战性的过程。在本期Cell Stem Cell 中,Kruta 等人。(2021) 将热休克因子 1 (Hsf1) 确定为维持 HSC 健康和蛋白质稳态的新目标,不仅在培养条件下,而且在老化时也是如此。

更新日期:2021-11-04
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