Expanding hematopoietic stem cells (HSCs) ex vivo has historically been a very challenging process. In this issue of Cell Stem Cell, Kruta et al. (2021) identify heat shock factor 1 (Hsf1) as a new target to maintain HSC fitness and protein homeostasis, not only in culture conditions but also upon aging.

中文翻译：

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避免电击您的造血干细胞，让它们保持年轻和成长

扩增造血干细胞（HSCs）体外历来一个非常具有挑战性的过程。在本期Cell Stem Cell 中，Kruta 等人。(2021) 将热休克因子 1 (Hsf1) 确定为维持 HSC 健康和蛋白质稳态的新目标，不仅在培养条件下，而且在老化时也是如此。