Elevated brain natriuretic peptide (BNP) and the N-terminal fragment of its pro-hormone (NT-proBNP) have become established biomarkers for heart failure and are associated with cardiovascular morbidity and mortality. Investigating sources of inter-individual heterogeneity, particularly genetic factors, could help better identify patients at risk of future cardiovascular disease. The aim of this study was to estimate the heritability of circulating NT-proBNP levels, to perform a genome-wide association study (GWAS) and gene-candidate analysis focused on NPPB–NPPA genes on these levels, and to examine their association with cardiovascular or metabolic outcomes.

中文翻译：

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利钠肽多态性对人群队列舒张功能和代谢功能的影响：来自 STANISLAS 队列的见解

升高的脑利钠肽 (BNP) 及其激素原的 N 端片段 (NT-proBNP) 已成为心力衰竭的既定生物标志物，并与心血管疾病的发病率和死亡率相关。调查个体间异质性的来源，特别是遗传因素，可以帮助更好地识别未来有心血管疾病风险的患者。本研究的目的是评估循环 NT-proBNP 水平的遗传力，进行全基因组关联研究 (GWAS) 和基因候选分析，重点关注这些水平上的NPPB-NPPA基因，并检查它们与心血管疾病的关联。或代谢结果。