An overview of the application of natural and synthetic, non-viral vectors for oligonucleotide delivery into the lung is presented in this review, with a special focus on lung cancer. Due to the specificity of the respiratory tract, its structure and natural barriers, the administration of drugs (especially those based on nucleic acids) is a particular challenge.

Among widely tested non-viral drug and oligonucleotides carriers, synthetic polymers seem to be most promising. Unique properties of these nanoparticles allow for essentially unlimited possibilities regarding their design and modification. This gives hope that optimal nanoparticles with ideal nucleic acid carrier properties for lung cancer therapy will eventually emanate.

本综述概述了天然和合成的非病毒载体在将寡核苷酸递送到肺中的应用，特别关注肺癌。由于呼吸道的特异性、其结构和天然屏障，药物（尤其是基于核酸的药物）的给药是一个特殊的挑战。

在广泛测试的非病毒药物和寡核苷酸载体中，合成聚合物似乎是最有前途的。这些纳米粒子的独特性质为它们的设计和修改提供了基本上无限的可能性。这带来了希望，最终会出现具有理想核酸载体特性的用于肺癌治疗的最佳纳米粒子。