Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease and the seventh cause of cancer-related death worldwide.1 Notably, clinical characteristics, response to chemotherapy and progression of PDAC can vary among patients. Thus, huge efforts on the molecular profiling of cancer specimens have been undertaken during the last decade. Large-scale gene expression studies defined two main PDAC subtypes with either a ‘classical’ or ‘basal-like’ transcriptional signature, with patients with the basal-like subtype having a significantly poorer overall survival.2–4 Basal cells are a cell type predominantly located in the basal layer of stratified and pseudostratified epithelia in several tissues, including the skin, oesophagus, lung and breast. Common basal cell markers include keratin5 ( KRT5 ) and tumour protein P63 ( TP63 ), a member of the TP53 transcription factor family. In the pulmonary airway, the oesophagus and the mammary gland, basal cells serve as multipotent stem cells or progenitor-like cells which can give rise to organ-specific, terminally differentiated cells and thus have an important role in tissue regeneration on injury.5 6 Though basal cells have been found in several glandular organs, the pancreas is …

中文翻译：

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胰腺基底细胞的发现：成体干细胞的新候选者出现


胰腺导管腺癌 (PDAC) 是一种毁灭性疾病，是全球癌症相关死亡的第七大原因。1 值得注意的是，PDAC 的临床特征、化疗反应和进展可能因患者而异。因此，在过去十年中，人们在癌症样本的分子分析方面付出了巨大的努力。大规模基因表达研究定义了两种主要的 PDAC 亚型，具有“经典”或“基底样”转录特征，基底样亚型患者的总体生存率明显较差。2–4 基底细胞是一种细胞类型主要位于皮肤、食道、肺和乳房等多种组织的复层和假复层上皮的基底层。常见的基底细胞标志物包括角蛋白5 (KRT5) 和肿瘤蛋白P63 (TP63)，TP53 转录因子家族的成员。在肺气道、食道和乳腺中，基底细胞充当多能干细胞或类祖细胞，可以产生器官特异性的终末分化细胞，因此在损伤后的组织再生中具有重要作用。 5 6尽管在几个腺体器官中发现了基底细胞，但胰腺......