Reconfiguring workup steps in multi-cycle extractive bioconversion for sustainable fatty alcohol production: a process engineering approach,Reaction Chemistry & Engineering

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Reconfiguring workup steps in multi-cycle extractive bioconversion for sustainable fatty alcohol production: a process engineering approach
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2021-10-15 , DOI: 10.1039/d1re00394a
Supacha Buttranon ₁ , Juthamas Jaroensuk ₁ , Patchara Chaichol ₁ , Pimchai Chaiyen ₁ , Nopphon Weeranoppanant _{1,

2}

Affiliation

In situ extraction offers an effective way to recover products during microbial production of fatty alcohols, which can be operated in multi-cycle mode. Workup steps may be required to increase the driving force for the extraction or to minimize by-product accumulation. Different workup steps, including intermittent glucose addition, dodecane change, and buffer change, were investigated in this study. We demonstrated that reconfiguration of these workup steps (e.g. rare intermittent workup steps) between bioconversion cycles led to significantly improved productivity and sustainability. The optimized reconfiguration enhanced the yield (0.071 g fatty alcohol per g glucose) while reducing the E-factor to 34.98, which was 120-fold lower than that of the control condition without in situ extraction. The results from this work shed light on the sustainable process development of the fatty alcohol production.

中文翻译：

重新配置多循环提取生物转化的后处理步骤以实现可持续脂肪醇生产：一种工艺工程方法

原位提取提供了一种在脂肪醇微生物生产过程中回收产品的有效方法，该方法可以在多循环模式下运行。可能需要后处理步骤来增加提取的驱动力或最小化副产品的积累。本研究调查了不同的处理步骤，包括间歇性葡萄糖添加、十二烷更换和缓冲液更换。我们证明了在生物转化周期之间重新配置这些处理步骤（例如罕见的间歇性处理步骤）可以显着提高生产力和可持续性。优化的重构提高了产量（每克葡萄糖 0.071 克脂肪醇），同时降低了E-因子为 34.98，比没有原位提取的对照条件低 120 倍。这项工作的结果阐明了脂肪醇生产的可持续工艺发展。

更新日期：2021-11-16

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