Engineered Repeat Protein Hybrids: The New Horizon for Biologic Medicines and Diagnostic Tools,Accounts of Chemical Research

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Engineered Repeat Protein Hybrids: The New Horizon for Biologic Medicines and Diagnostic Tools
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2021-11-03 , DOI: 10.1021/acs.accounts.1c00440
Kepa B Uribe ₁ , Eduardo Guisasola ₁ , Antonio Aires ₁ , Elena López-Martínez ₁ , Gabriela Guedes ₁ , Ivan R Sasselli ₁ , Aitziber L Cortajarena _{1,

2}

Affiliation

The last decades have witnessed unprecedented scientific breakthroughs in all the fields of knowledge, from basic sciences to translational research, resulting in the drastic improvement of the lifespan and overall quality of life. However, despite these great advances, the treatment and diagnosis of some diseases remain a challenge. Inspired by nature, scientists have been exploring biomolecules and their derivatives as novel therapeutic/diagnostic agents. Among biomolecules, proteins raise much interest due to their high versatility, biocompatibility, and biodegradability.

中文翻译：

工程重复蛋白质杂交体：生物药物和诊断工具的新视野

过去几十年，从基础科学到转化研究，所有知识领域都取得了前所未有的科学突破，导致寿命和整体生活质量的大幅提高。然而，尽管取得了这些巨大进步，一些疾病的治疗和诊断仍然是一个挑战。受到大自然的启发，科学家们一直在探索生物分子及其衍生物作为新型治疗/诊断剂。在生物分子中，蛋白质由于其高度的多功能性、生物相容性和生物可降解性而引起了人们的广泛关注。

更新日期：2021-11-16

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