Twenty six novel pyrimidin-4-amine derivatives containing the 1,2,4-oxadiazole motif were synthesized. Their chemical structures were confirmed by ¹H nuclear magnetic resonance (NMR), ¹³C NMR, and highresolution mass spectrography. The insecticidal activity results indicated that some of them possessed excellent insecticidal activity (100%) against Mythimna separate, especially for compounds 6d, 6f, 6o, 6w, 6y and 6z. These compounds exhibited no activity against the insects Aphis medicagini and Tetranychus cinnabarinus. The structure-insecticidal activity relationships are discussed. Density functional theory analysis can potentially be used to design more active compounds. These results provide useful insecticide design information for further optimization.

合成了 26 种含有 1,2,4-恶二唑基序的新型嘧啶-4-胺衍生物。它们的化学结构经¹ H 核磁共振 (NMR)、¹³ C NMR 和高分辨率质谱证实。杀虫活性结果表明，其中部分化合物对Mythimna分离物具有优异的杀虫活性（100%），尤其是化合物6d、6f、6o、6w、6y和6z。这些化合物对昆虫Aphis medicagini和Tetranychus cinnabarinus没有表现出活性. 讨论了结构-杀虫活性关系。密度泛函理论分析可潜在地用于设计更具活性的化合物。这些结果为进一步优化提供了有用的杀虫剂设计信息。