Purpose: 

To evaluate the morphologic features of macular neovascularization (MNV) trunks at different layers using optical coherence tomography angiography.

Methods: 

Type 1 MNV trunks in age-related macular degeneration were retrospectively evaluated at the subretinal pigment epithelium and sub-Bruch membrane (subBM) layers. The detectability and location of the trunks were compared. MNV trunks at the subBM layer on optical coherence tomography angiography B-scans were evaluated using a flow overlay. The correlations of the MNV trunk with optical coherence tomography angiography and optical coherence tomography parameters were evaluated.

Results: 

Among the 63 included eyes, 27 showed core vessels at the subretinal pigment epithelium layer and 52 showed MNV trunks at the subBM layer, which were connected with the MNV at the subretinal pigment epithelium layer. The locations of the MNV trunks in each layer were different. MNV trunk types at the subBM layer were related to disease duration, distance from the large choroidal vessels, and MNV vessel density. The large choroidal vessel diameter was correlated with the MNV trunk diameter at the subBM layer.

Conclusion: 

Macular neovascularization trunks at the subBM layer were detected more frequently than distal MNV trunks at the subretinal pigment epithelium layer. Macular neovascularization trunk features at the subBM layer may be related to disease duration and a large choroidal vessel.

中文翻译：

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年龄相关性黄斑变性中 1 型黄斑新血管化干的形态学和解剖学特征使用光学相干断层造影血管造影

目的： 

使用光学相干断层扫描血管造影评估不同层黄斑新生血管（MNV）主干的形态学特征。

方法： 

对年龄相关性黄斑变性中的 1 型 MNV 主干在视网膜下色素上皮和亚布鲁赫膜 (subBM) 层进行了回顾性评估。比较了树干的可检测性和位置。使用流动叠加评估光学相干断层扫描血管造影 B 扫描中 subBM 层的 MNV 主干。评估了 MNV躯干与光学相干断层扫描血管造影和光学相干断层扫描参数的相关性。

结果： 

纳入的63只眼中，27只眼在视网膜下色素上皮层显示核心血管，52只在亚BM层显示MNV干，在视网膜下色素上皮层与MNV相连。MNV 主干在每一层的位置是不同的。subBM 层的MNV主干类型与疾病持续时间、与大脉络膜血管的距离和 MNV 血管密度有关。大脉络膜血管直径与subBM 层的 MNV主干直径相关。

结论： 

subBM 层的黄斑新生血管主干比视网膜下色素上皮层的远端 MNV 主干更频繁地检测到。subBM 层的黄斑新生血管主干特征可能与疾病持续时间和较大的脉络膜血管有关。