Purpose

To evaluate ocular surface manifestations in patients with acne rosecea (AR) and to find out main features indicating a propensity toward an association with disease diagnosis.

Methods

Right eyes of consecutive 76 AR patients and 113 age-gender matched healthy subjects were enrolled. Ophthalmologic examinations including tear break-up time (t-BUT) and Schirmer-2 tests to analyze tear film insufficiency, optical coherence tomography (OCT)-assisted infrared meibography to analyze meibomian gland drop-out, and Ocular Surface Disease Index (OSDI) questionnaire were performed in all participants.

Results

No statistically differences were found in visual acuity, intraocular pressure, central corneal thickness, and axial length assessments between the study and control eyes. Study eyes had more foreign body sensation, itching, dryness, hyperemia, conjunctival telangiectasia, and meibomitis (p ≤ 0.005, for all). Significantly higher t-BUT and Schirmer-2 tests; lower-eyelid and total OCT meibography; and OSDI scores were found in AR patients (p < 0.05, for all). Among all, only conjunctival telangiectasia (p = 0.001; OR:0.070, 95% CI:0.015–0.330) was found to be major independent predictor for AR diagnosis.

Conclusion

Detailed slit-lamp examination to detect any conjunctival telangiectasia seems to be crucial in recalcitrant dry eye cases, not to miss underlying AR. Especially, lower-eyelid OCT meibography score may be sensitively used for disease staging.

中文翻译：

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酒渣鼻患者常见的眼部表现

目的

评估玫瑰痤疮 (AR) 患者的眼表表现，并找出表明与疾病诊断相关的主要特征。

方法

连续招募了 76 名 AR 患者和 113 名年龄性别匹配的健康受试者的右眼。眼科检查包括泪液破裂时间 (t-BUT) 和 Schirmer-2 测试以分析泪膜功能不全、光学相干断层扫描 (OCT) 辅助红外光成像分析睑板腺脱落和眼表疾病指数 (OSDI)对所有参与者进行问卷调查。

结果

在研究和对照眼之间的视力、眼压、中央角膜厚度和眼轴长度评估方面没有发现统计学差异。研究的眼睛有更多的异物感、瘙痒、干燥、充血、结膜毛细血管扩张和睑板腺炎（全部p  ≤ 0.005）。显着更高的 t-BUT 和 Schirmer-2 测试；下眼睑和全 OCT 睑板腺成像；在 AR 患者中发现和 OSDI 评分（p  < 0.05，对于所有）。其中，仅结膜毛细血管扩张（p  = 0.001；OR：0.070，95% CI：0.015-0.330）被发现是 AR 诊断的主要独立预测因子。

结论

详细的裂隙灯检查以检测任何结膜毛细血管扩张似乎对于顽固性干眼病例至关重要，不要错过潜在的 AR。特别是，下眼睑OCT meibography评分可敏感地用于疾病分期。