Background

N-isopropyl- (¹²³I) p-iodoamphetamine (¹²³I-IMP) is specifically accumulated in primary central nervous system lymphoma (PCNSL) during single-photon emission tomography (SPECT) and contributes to its diagnostic imaging. However, whether ¹²³I-IMP is accumulated in ocular adnexal lymphoma (OAL), one of the malignant intraorbital tumors, remains unclear. This study aimed to evaluate the diagnostic value of ¹²³I-IMP SPECT in OAL.

Methods

Between August 2005 and June 2020, 26 patients with intraorbital tumors underwent neurosurgery at the tertiary care center. Of these, 15 patients who underwent ¹²³I-IMPSPECT before surgery were retrospectively examined. The region of interest was set in the cerebellum ipsilateral to the intraorbital tumor on ¹²³I-IMP SPECT, and the tumor-to-cerebellum ratio (T/C ratio) was calculated using the following formula: T/C ratio = [accumulation of tumor (count/pixel)]/[accumulation of ipsilateral normal cerebellar hemisphere (count/pixel)].

Results

Six patients were included in the OAL group, who were pathologically diagnosed with extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), diffuse large B-cell lymphoma (DLBCL), and plasmacytoma. The T/C ratio in the OAL group was statistically higher than that in the non-OAL group (p < 0.01). The optimal cutoff values for both groups were between 0.76 and < 0.93. The sensitivity and specificity were 1.00, respectively.

Conclusions

¹²³I-IMP SPECT is useful as one of the examinations in the differential diagnoses of OAL, because it showed a significantly higher accumulation in OAL group than in non-OAL group.

中文翻译：

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123I-IMP SPECT对眼附件淋巴瘤的诊断价值

背景

N-异丙基- ( ¹²³ I) 对碘苯丙胺 ( ¹²³ I-IMP) 在单光子发射断层扫描 (SPECT) 期间特异性地积聚在原发性中枢神经系统淋巴瘤 (PCNSL) 中，并有助于其诊断成像。然而，¹²³ I-IMP 是否在眼附件淋巴瘤 (OAL)（一种恶性眼眶内肿瘤）中蓄积尚不清楚。本研究旨在评价¹²³ I-IMP SPECT 在 OAL 中的诊断价值。

方法

2005 年 8 月至 2020 年 6 月期间，26 名眶内肿瘤患者在三级医疗中心接受了神经外科手术。其中，对术前接受¹²³ I-IMPSPECT 的 15 名患者进行了回顾性检查。^在123 I-IMP SPECT上将感兴趣区域设置在眶内肿瘤同侧的小脑中，并使用以下公式计算肿瘤与小脑的比率（T/C 比率）：T/C 比率 = [累积的肿瘤（个/像素）]/[同侧正常小脑半球的累积（个/像素）]。

结果

OAL组6例患者，病理诊断为粘膜相关淋巴组织结外边缘区B细胞淋巴瘤（MALT淋巴瘤）、弥漫性大B细胞淋巴瘤（DLBCL）和浆细胞瘤。OAL 组的 T/C 比在统计学上高于非 OAL 组 ( p  < 0.01)。两组的最佳临界值介于 0.76 和 < 0.93 之间。灵敏度和特异性分别为 1.00。

结论

¹²³ I-IMP SPECT 可作为 OAL 鉴别诊断的检查之一，因为它显示 OAL 组的蓄积显着高于非 OAL 组。