The methodology to distinguish between the heart failure (HF) with recovered ejection fraction (HFrecEF) and those with continuously reduced ejection fraction (EF) (HFcrEF) on admission has not been established. We recently demonstrated that the ratio of plasma levels of pro-B-type natriuretic peptide (proBNP) to total BNP (proBNP plus mature BNP) is decreased on admission in patients with mild acute HF, but not in severe acute HF as a compensatory mechanism for activating cyclic GMP via increases of bioactive mature BNP. We aimed to test the hypothesis that the ratio of bioactive mature BNP to total BNP is associated with reverse remodelling capacity in patients with HF with reduced EF.

中文翻译：

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急性心力衰竭中成熟B型利钠肽的分子比：心室收缩恢复的指标

尚未建立区分射血分数恢复的心力衰竭 (HF) (HFrecEF) 和入院时射血分数持续降低 (EF) (HFcrEF) 的方法。我们最近证明，在轻度急性 HF 患者入院时，血浆前 B 型利钠肽 (proBNP) 与总 BNP（proBNP 加成熟 BNP）的比率降低，但在作为代偿机制的重度急性 HF 患者中没有用于通过增加具有生物活性的成熟 BNP 来激活环状 GMP。我们旨在验证生物活性成熟 BNP 与总 BNP 的比率与 EF 降低的 HF 患者的逆向重塑能力相关的假设。