White adipose tissue is the primary site of energy storage to maintain metabolic function of the organism at times of starvation. Moreover, a multitude of hormones, cytokines and other bioactive molecules secreted from adipose tissue regulate key aspects of systemic metabolism.1 2 In mammals adipose is organised in multiple depots throughout the body differing in size, developmental origin and function.1 2 These depots are divided into subcutaneous and visceral adipose tissues. Although individual depots within these categories differ between species, for example, humans and mice, excessive accumulation of fat in visceral adipose associates with impaired insulin sensitivity and the development of the metabolic syndrome, whereas increase in subcutaneous adipose mass does not show this association.1 3 Given the central role of adipose tissue in the regulation of systemic lipid and glucose homoeostasis and the ever-increasing details known on cellular composition and function of adipocytes within the large adipose depots, it is surprising that some adipose tissues remain barely studied. In GUT , Krieg and colleagues perform a detailed multi-omics comparison and characterisation of human epiploic fat with subcutaneous, omental and mesenteric fat of insulin sensitive and insulin resistant subjects. Epiploic fat is part of visceral adipose tissue located along the colon …

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网膜脂肪是肠道的真皮脂肪吗？

白色脂肪组织是能量储存的主要部位，以在饥饿时维持生物体的代谢功能。此外，脂肪组织分泌的大量激素、细胞因子和其他生物活性分子调节全身代谢的关键方面。 1 2 在哺乳动物中，脂肪组织在整个身体的多个仓库中，大小、发育起源和功能各不相同。 1 2 这些仓库是分为皮下脂肪组织和内脏脂肪组织。尽管这些类别中的个体仓库在物种之间有所不同，例如人类和小鼠，但内脏脂肪中脂肪的过度积累与胰岛素敏感性受损和代谢综合征的发展有关，而皮下脂肪量的增加并未显示出这种关联。1 3 鉴于脂肪组织在调节全身脂质和葡萄糖稳态中的核心作用，以及关于大型脂肪库内脂肪细胞的细胞组成和功能的不断增加的细节，令人惊讶的是，一些脂肪组织仍然很少被研究。在 GUT，Krieg 及其同事对胰岛素敏感和胰岛素抵抗受试者的皮下脂肪、网膜脂肪和肠系膜脂肪进行了详细的多组学比较和表征。网膜脂肪是位于结肠沿线的内脏脂肪组织的一部分…… Krieg 及其同事对胰岛素敏感和胰岛素抵抗受试者的皮下脂肪、网膜脂肪和肠系膜脂肪进行了详细的多组学比较和表征。网膜脂肪是位于结肠沿线的内脏脂肪组织的一部分…… Krieg 及其同事对胰岛素敏感和胰岛素抵抗受试者的皮下脂肪、网膜脂肪和肠系膜脂肪进行了详细的多组学比较和表征。网膜脂肪是位于结肠沿线的内脏脂肪组织的一部分……