Objective To assess the prevalence and clinical implications of persistent or exertional cardiopulmonary symptoms in young competitive athletes following SARS-CoV-2 infection. Methods This observational cohort study from the Outcomes Registry for Cardiac Conditions in Athletes included 3597 US collegiate athletes after SARS-CoV-2 infection. Clinical characteristics, advanced diagnostic testing and SARS-CoV-2-associated sequelae were compared between athletes with persistent symptoms >3 weeks, exertional symptoms on return to exercise and those without persistent or exertional symptoms. Results Among 3597 athletes (mean age 20 years (SD, 1 year), 34% female), data on persistent and exertional symptoms were reported in 3529 and 3393 athletes, respectively. Persistent symptoms >3 weeks were present in 44/3529 (1.2%) athletes with 2/3529 (0.06%) reporting symptoms >12 weeks. Exertional cardiopulmonary symptoms were present in 137/3393 (4.0%) athletes. Clinical evaluation and diagnostic testing led to the diagnosis of SARS-CoV-2-associated sequelae in 12/137 (8.8%) athletes with exertional symptoms (five cardiac involvement, two pneumonia, two inappropriate sinus tachycardia, two postural orthostatic tachycardia syndrome and one pleural effusion). No SARS-CoV-2-associated sequelae were identified in athletes with isolated persistent symptoms. Of athletes with chest pain on return to exercise who underwent cardiac MRI (CMR), 5/24 (20.8%) had probable or definite cardiac involvement. In contrast, no athlete with exertional symptoms without chest pain who underwent CMR (0/20) was diagnosed with probable or definite SARS-CoV-2 cardiac involvement. Conclusion Collegiate athletes with SARS-CoV-2 infection have a low prevalence of persistent or exertional symptoms on return to exercise. Exertional cardiopulmonary symptoms, specifically chest pain, warrant a comprehensive evaluation. Data are available upon reasonable request.

中文翻译：

---

3597 名大学生运动员感染 SARS-CoV-2 后持续性或劳力性心肺症状的患病率和临床意义：运动员心脏疾病结果登记处 (ORCCA) 的一项研究

目的 评估 SARS-CoV-2 感染后年轻竞技运动员持续或劳力性心肺症状的患病率和临床意义。方法 这项来自运动员心脏状况结果登记处的观察性队列研究包括 3597 名 SARS-CoV-2 感染后的美国大学运动员。比较了持续症状 > 3 周、恢复运动时出现劳累症状的运动员和没有持续或劳累症状的运动员的临床特征、先进的诊断测试和 SARS-CoV-2 相关后遗症。结果 在 3597 名运动员（平均年龄 20 岁（SD，1 岁），34% 为女性）中，分别报告了 3529 名和 3393 名运动员的持续和劳累症状数据。44/3529 (1.2%) 名运动员出现持续症状 > 3 周，其中 2/3529 (0. 06%) 报告症状 > 12 周。137/3393 (4.0%) 名运动员出现劳累性心肺症状。临床评估和诊断测试导致 12/137 (8.8%) 名有劳力症状的运动员被诊断为 SARS-CoV-2 相关后遗症（5 例心脏受累、2 例肺炎、2 例不适当的窦性心动过速、2 例体位性体位性心动过速综合征和 1 例）胸腔积液）。在具有孤立性持续症状的运动员中未发现与 SARS-CoV-2 相关的后遗症。在接受心脏 MRI (CMR) 的恢复运动时出现胸痛的运动员中，5/24 (20.8%) 可能或明确心脏受累。相比之下，在接受 CMR (0/20) 的没有胸痛的劳累症状的运动员中，没有人被诊断为可能或明确的 SARS-CoV-2 心脏受累。结论 感染 SARS-CoV-2 的大学生运动员在恢复运动后出现持续性或劳累性症状的患病率较低。劳累性心肺症状，特别是胸痛，需要进行全面评估。可根据合理要求提供数据。