PURPOSE

To assess ocular biometric determinants of dark-to-light change in anterior chamber angle width and identify dynamic risk factors in primary angle closure disease (PACD).

DESIGN

Population-based cross-sectional study.

METHODS

Chinese American Eye Study (CHES) participants underwent anterior segment optical coherence tomography imaging in the dark and light. Static dark and light biometric parameters, including angle opening distance, 750 µm (AOD750), anterior chamber width (ACW), lens vault (LV), and pupillary diameter (PD) were measured, and dynamic dark-to-light changes were calculated. Contributions by static and dynamic parameters to dark-to-light changes in AOD750 were assessed using multivariable linear regression models with standardized regression coefficients (SRCs) and semipartial correlation coefficients squared (SPCC²). PACD was defined as ≥3 quadrants of gonioscopic angle closure.

RESULTS

The analysis included 1011 participants. All biometric parameters differed between dark and light (P < .05). On multivariable regression analysis, change in ACW (SRC = −0.35, SPCC² = 0.081) and PD (SRC = −0.46, SPCC² = 0.072) were the strongest determinants of dark-to-light change in AOD750 (overall R² = 0.40). Dark-to-light increase in AOD750 was less in eyes with than without PACD (0.081 mm and 0.111 mm, respectively; P < .001). ACW increased in eyes with PACD and decreased in eyes without PACD from dark to light (P < .025), whereas change in PD was similar (P = .28).

CONCLUSIONS

Beneficial angle widening effects of transitioning from dark to light are attenuated in eyes with PACD, which appears related to aberrant dark-to-light change in ACW. These findings highlight the importance of assessing the angle in both dark and light to identify potential dynamic mechanisms of angle closure.

中文翻译：

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角宽从暗到亮变化的眼部生物特征决定因素：美国华人眼科研究

目的

评估前房角宽度从暗到亮变化的眼部生物特征决定因素，并确定原发性闭角病 (PACD) 的动态危险因素。

设计

基于人群的横断面研究。

方法

美籍华人眼科研究 (CHES) 参与者在黑暗和光线下接受了眼前节光学相干断层扫描成像。测量静态暗光和光生物特征参数，包括开角距离、750 µm (AOD750)、前房宽度 (ACW)、晶状体拱顶 (LV) 和瞳孔直径 (PD)，并计算动态暗光到光的变化. ^{使用具有标准化回归系数 (SRC) 和半偏相关系数平方 (SPCC 2} ) 的多变量线性回归模型评估静态和动态参数对 AOD750 从暗到亮变化的贡献。PACD 被定义为房角镜角度闭合≥3 个象限。

结果

分析包括 1011 名参与者。所有生物特征参数在黑暗和光明之间都不同 ( P < .05)。在多变量回归分析中，ACW（SRC = −0.35，SPCC ²  = 0.081）和 PD（SRC = −0.46，SPCC ²  = 0.072）的变化是 AOD750 中暗到亮变化的最强决定因素（总体R ²  = 0.40）。有 PACD 的眼睛比没有 PACD 的眼睛从暗到亮的 AOD750 增加更少（分别为 0.081 毫米和 0.111 毫米；P < .001）。ACW 在患有 PACD 的眼睛中增加，而在没有 PACD 的眼睛中从黑暗到明亮减少 ( P < .025)，而 PD 的变化是相似的 ( P  = .28)。

结论

在 PACD 眼中，从暗到亮过渡的有益角度扩大效应会减弱，这似乎与 ACW 中异常的暗到亮变化有关。这些发现强调了评估黑暗和光线角度以确定角度闭合的潜在动态机制的重要性。