Virus-like particles (VLPs) are known as self-assembled, non-replicative and non-infectious protein particles, which imitate the formation and structure of original wild type viruses, however, lack the viral genome and/or their fragments. The capacity of VLPs to encompass small molecules like nucleic acids and others has made them as novel vessels of nanocarriers for drug delivery applications. In addition, VLPs surface have the capacity to achieve variation of the surface display via several modification strategies including genetic modification, chemical modification, and non-covalent modification. Among the VLPs nanocarriers, Hepatitis B virus core (HBc) particles have been the most encouraging candidate. HBc particles are hollow nanoparticles in the range of 30–34 nm in diameter and 7 nm thick envelopes, consisting of 180 or 240 copies of identical polypeptide monomer. They also employ a distinctive position among the VLPs carriers due to the high-level synthesis, which serves as a strong protective capsid shell and efficient self-assembly properties. This review highlights on the bioengineering of HBc particles as dynamic nanocarriers for in vivo delivery and specific targeting to solid tumours.

病毒样颗粒（VLPs）被称为自组装、非复制和非感染性蛋白质颗粒，它模仿原始野生型病毒的形成和结构，但缺乏病毒基因组和/或其片段。VLP 包含小分子（如核酸等）的能力使其成为用于药物递送应用的新型纳米载体容器。此外，VLPs 表面具有通过以下方式实现表面显示变化的能力几种修饰策略，包括遗传修饰、化学修饰和非共价修饰。在 VLPs 纳米载体中，乙型肝炎病毒核心 (HBc) 颗粒是最令人鼓舞的候选者。HBc 颗粒是直径为 30-34 nm 和 7 nm 厚包膜的中空纳米颗粒，由 180 或 240 个相同的多肽单体组成。由于高水平的合成，它们在 VLP 载体中也具有独特的地位，可作为强大的保护衣壳和高效的自组装特性。本综述重点介绍了 HBc 颗粒作为用于体内递送和特异性靶向实体瘤的动态纳米载体的生物工程。