Chemical & Pharmaceutical Bulletin ( IF 1.5 ) Pub Date : 2021-11-01 , DOI: 10.1248/cpb.c21-00537 Kaname Hashizaki 1 , Yuto Hoshii 1 , Kosuke Ikeuchi 1 , Miko Imai 1 , Hiroyuki Taguchi 1 , Yukihiro Goto 2 , Makiko Fujii 1
Our aim was to determine the surface free energy (SFE) of semi-solid dosage forms (SSDFs) by establishing a reproducible method for measuring the contact angle of liquids to SSDFs. Four SSDFs were used: petrolatum, an oil/water (O/W) and a water/oil (W/O) cream, and an alcohol-based gel. The SSDFs were evenly spread on a glass slide, and the change in contact angle over time was measured by dropping water, glycerol, diiodomethane and n-hexadecane as the test liquids. Depending on the combination of test liquid and SSDF, the contact angle was either constant or decreased in an exponential manner. Contact angles may have decreased in an exponential manner because the reaction between the test liquid and the SSDF altered the interfacial tension between the two phases and changed the surface tension of the test liquid and the SFE of the SSDF. The contact angle of the test liquid to the SSDF could be determined reproducibly using the initial contact angle immediately after dropping the liquid on the SSDF as the contact angle before reaction. Using the obtained contact angles and the Owens–Wendt–Rabel–Kaelble equation, we calculated the SFE and its component for the SSDFs tested and found that the results reflect the physicochemical properties of SSDFs. Furthermore, the work of adhesion (WA) of the SSDF to Yucatan micropig skin was calculated using the SFE for the SSDFs. Interestingly, the WA values for all SSDFs tested were comparable.
Fullsize Image中文翻译:
一种测量外用半固体剂型表面自由能的方法
我们的目标是通过建立一种可重现的方法来测量液体与 SSDF 的接触角,从而确定半固体剂型 (SSDF) 的表面自由能 (SFE)。使用了四种 SSDF:凡士林、油/水 (O/W) 和水/油 (W/O) 乳膏,以及基于酒精的凝胶。SSDFs 均匀分布在载玻片上,通过滴水、甘油、二碘甲烷和n来测量接触角随时间的变化-十六烷作为测试液体。根据测试液体和 SSDF 的组合,接触角是恒定的或以指数方式减小。接触角可能以指数方式下降,因为测试液体和 SSDF 之间的反应改变了两相之间的界面张力,并改变了测试液体的表面张力和 SSDF 的 SFE。测试液体与 SSDF 的接触角可以使用将液体滴在 SSDF 上后立即的初始接触角作为反应前的接触角来重复确定。使用获得的接触角和 Owens-Wendt-Rabel-Kaelble 方程,我们计算了所测试 SSDF 的 SFE 及其分量,发现结果反映了 SSDF 的物理化学性质。此外,SSDF 对尤卡坦微型猪皮的W A ) 使用 SSDF 的 SFE 计算。有趣的是,所有测试的 SSDF的W A值都具有可比性。
全尺寸图像