Aim: The aim of the study was to assess the acceptance of patients with opioid use disorder (OUD) to switching their opioid dependence treatment (ODT) for a prolonged-release buprenorphine (PRB) injection according to their prior ODT (buprenorphine/naloxone [B/N] or methadone). Methods: This was an observational, retrospective/cross-sectional, multicentre study of adult patients diagnosed with OUD on ODT. Data collected from diaries were analysed to know their interest and opinion on PRB. Questions with fixed response options were included, and several Likert scales were used. Results: A total of 98 patients were enrolled (B/N: 50.0%, methadone: 50.0%). The mean age was 46.9 ± 8.43 years and 79.6% were males. PRB was similarly perceived by both groups in most variables analysed, receiving a mean score of 7.2/10 (B/N: 7.4, methadone: 7.0; p = 0.520), and approximately 65% of patients said they were willing to switch to PRB (B/N: 63.3%, methadone: 65.3%; p = 0.833). Of these, a higher percentage in the B/N group considered that switching would be easy/very easy (B/N: 90.3%, methadone: 46.9%; p #x3c; 0.001) and that they would start PRB when available (B/N: 64.5%, methadone: 34.3%; p = 0.005). More than 90% would prefer the monthly injection (B/N: 93.6%, methadone: 100%; p = 0.514). One-third of patients in both groups were unsure/would not switch their ODT to PRB (B/N: 36.7%, methadone: 34.7%; p = 0.833). The main reason was administration by injection. Conclusion: Two-thirds of patients would switch their treatment for PRB, and most patients on B/N considered that switching would be easy. PRB could be a suitable alternative for OUD management.
Eur Addict Res

中文翻译：

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阿片类药物使用障碍患者对新型缓释丁丙诺啡制剂的看法：PREDEPO 研究

目的：该研究的目的是评估阿片类药物使用障碍 (OUD) 患者对阿片类药物依赖治疗 (ODT) 的接受程度，根据他们之前的 ODT（丁丙诺啡/纳洛酮 [ B/N] 或美沙酮）。方法：这是一项针对 ODT 诊断为 OUD 的成年患者的观察性、回顾性/横断面、多中心研究。分析从日记中收集的数据，以了解他们对 PRB 的兴趣和意见。包括具有固定响应选项的问题，并使用了几个李克特量表。结果：共招募了 98 名患者（B/N：50.0%，美沙酮：50.0%）。平均年龄为 46.9 ± 8.43 岁，79.6% 为男性。在大多数分析的变量中，两组对 PRB 的看法相似，平均得分为 7.2/10（B/N：7.4，美沙酮：7.0；p = 0.520），大约 65% 的患者表示他们愿意改用 PRB （B/N：63.3%，美沙酮：65.3%；p = 0.833）。其中，较高比例的 B/N 组认为转换很容易/非常容易（B/N：90.3%，美沙酮：46.9%；p #x3c；0.001）并且他们会在可用时开始 PRB（B /N：64.5%，美沙酮：34.3%；p = 0.005)。超过 90% 的人更愿意每月注射一次（B/N：93.6%，美沙酮：100%；p= 0.514）。两组中有三分之一的患者不确定/不会将 ODT 转换为 PRB（B/N：36.7%，美沙酮：34.7%；p = 0.833）。主要原因是注射给药。结论：三分之二的患者会转用 PRB 治疗，大多数 B/N 患者认为转换很容易。PRB 可能是 OUD 管理的合适替代方案。
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