Graphical Abstract

Graphical AbstractThese bubble plots demonstrate the consistent reductions in time to cardiovascular mortality or first heart failure hospitalization with SGLT2 inhibitors across all trials, with a greater absolute risk reduction in patients at higher risk. The size of the bubble represents the sample size of the trial. Number needed to treat (NNT) is estimated from the absolute risk reduction Event rates of first heart failure hospitalization or cardiovascular mortality were not reported in SOLOIST-WHF; we used 12-month Kaplan Meier event rates estimated by Cotter et al.¹⁹

中文翻译：

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不同患者人群的钠葡萄糖协同转运蛋白抑制剂和心力衰竭结果

图形概要

图形摘要这些气泡图表明，在所有试验中，使用 SGLT2 抑制剂可以持续减少心血管死亡或首次心力衰竭住院的时间，高风险患者的绝对风险降低幅度更大。气泡的大小代表试验的样本大小。SOLOIST-WHF 中未报告首次心力衰竭住院或心血管死亡率的事件发生率；我们使用了 Cotter等人估计的 12 个月的 Kaplan Meier 事件率。¹⁹