HLA alleles associated with asparaginase hypersensitivity in Chinese children,Journal of Hematology & Oncology

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HLA alleles associated with asparaginase hypersensitivity in Chinese children
Journal of Hematology & Oncology ( IF 29.5 ) Pub Date : 2021-10-30 , DOI: 10.1186/s13045-021-01201-3
Gilbert T Chua _{1,

2} , Jaime S Rosa Duque _{1,

2} , Daniel Ka Leung Cheuk _{1,

2} , Alex Wing Kwan Leung _{2,

3} , Wilfred Hing Sang Wong ₁ , Anthony Pak Yin Liu _{1,

2} , Pamela P W Lee _{1,

2} , Shau Yin Ha _{1,

2} , Alan Kwok Shing Chiang _{1,

2} , Marco Hok Kung Ho ₁ , Wai Keung Chu ₄ , Yuk Sing Chan ₄ , Chun Wing Luk ₂ , Alvin Siu Cheung Ling ₂ , Mike Yat Wah Kwan ₅ , Oscar Kuen Fong Yiu ₁ , Ian Chi Kei Wong _{6,

7,

8} , Yu Lung Lau _{1,

2} , Chi Kong Li _{2,

3} , Wing Hang Leung _{1,

2} , Godfrey Chi Fung Chan _{1,

2} , Patrick Ip _{1,

2} , Janette Kwok ₄

Affiliation

Asparaginase is an important drug to treat childhood haematological malignancies. Data on the association between human leukocyte antigens (HLA) and asparaginase hypersensitivity among Chinese are lacking. We conducted a retrospective study to identify HLA alleles associated with asparaginase hypersensitivity among Chinese children with acute lymphoblastic leukaemia (ALL), mixed phenotype leukaemia and non-Hodgkin lymphoma (NHL), who received asparaginases with HLA typing performed between 2009 and 2019. 107 Chinese patients were analysed. 66.3% (71/107) developed hypersensitivity to at least one of the asparaginases. HLA-B*46:01 (OR 3.8, 95% CI 1.4–10.1, p < 0.01) and DRB1*09:01 (OR 4.3, 95% CI 1.6–11.4, p < 0.01) were significantly associated with l-asparaginase hypersensitivities, which remained significant after adjustment for age, gender and B cell ALL [HLA-B*46:01 (adjusted OR 3.5, 95% 1.3–10.5, p = 0.02) and DRB1*09:01 (OR 4.4, 95% CI 1.6–13.3, p < 0.01)].

更新日期：2021-10-31

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