Cholangiocarcinoma (CCA) is a malignancy arising from biliary epithelial cells of intra- and extrahepatic bile ducts with dismal prognosis and few nonsurgical treatments available. Despite recent success in the immunotherapy-based treatment of many tumor types, this has not been successfully translated to CCA. Mucosal-associated invariant T (MAIT) cells are cytotoxic innate-like T cells highly enriched in the human liver, where they are located in close proximity to the biliary epithelium. Here, we aimed to comprehensively characterize MAIT cells in intrahepatic (iCCA) and perihilar CCA (pCCA).

中文翻译：

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粘膜相关不变性 T 细胞肿瘤浸润预测胆管癌的长期生存

胆管癌 (CCA) 是一种由肝内和肝外胆管的胆道上皮细胞引起的恶性肿瘤，预后不佳，非手术治疗很少。尽管最近在许多肿瘤类型的基于免疫疗法的治疗中取得了成功，但这尚未成功转化为 CCA。粘膜相关不变性 T (MAIT) 细胞是细胞毒性先天样 T 细胞，在人类肝脏中高度富集，它们靠近胆道上皮细胞。在这里，我们旨在全面表征肝内 (iCCA) 和肺门周围 CCA (pCCA) 中的 MAIT 细胞。