PURPOSE To evaluate the accuracy of MultiColor imaging (MC) compared to fluorescein angiography (FA) in detecting proliferative diabetic retinopathy (PDR) and associated diabetic retinopathy features. METHODS Fifty-nine eyes from 38 PDR patients were included. MC images were reviewed by 2 independent masked graders. A qualitative analysis based on the following features was performed: neovascular complexes (NVC), disc neovascularization (NVD), neovascularization elsewhere (NVE), microaneurysm (MA), intraretinal hemorrhage (IRH), vitreous hemorrhage (VH), preretinal hemorrhage (PRH), fibrosis, hard exudates (HE), epiretinal membrane (ERM), diabetic macular edema (DME), ischemia and laser spots (LS). Measures of diagnostic accuracy compared to FA were determined. RESULTS The sensitivity for the detection of NVC using MC was 95.1%, with a specificity of 40.0%, positive predictive value (PPV) of 92.9% and negative predictive value (NPV) of 50.0%. Sensitivity and specificity were higher in detecting NVD (88.9% and 76.9%) while NVE registered higher PPV (88.9%). MC was highly sensitive in detecting IRH, HE, ERM and LS (100%), MA (98.0%) and fibrosis (95.5%). Highest specificity was found for VH (100.0%), DME (100.0%), PRH (98.1%) and LS (89.5%). The area under the receiver-operating characteristic analysis of MC was excellent in NVD (0.83, 95% confidence interval (CI), 0.71-0.95, p < 0.001), IRH (0.89, 95% CI 0.74-1.00, p < 0.001), VH (0.81, 95% CI 0.60-1.00, p = 0.005) and PRH (0.89, 95% CI 0.68-1.00, p = 0.004) and outstanding in LS detection (0.95, 95% CI 0.87-1.00, p < 0.001). These results are likely due to the contrast and quality of the MC since better discrimination is enabled by the green wavelength. CONCLUSION MC is useful in evaluation of PDR patients and can complement noninvasive imaging. MC detected some PDR features more accurately than FA such as NVD, IRH, VH, PRH, and LS.

中文翻译：

---

多色成像在检测增殖性糖尿病视网膜病变中的敏感性和特异性。

目的 评估多色成像 (MC) 与荧光素血管造影 (FA) 在检测增殖性糖尿病视网膜病变 (PDR) 和相关糖尿病视网膜病变特征方面的准确性。方法 包括来自 38 名 PDR 患者的 59 只眼。MC 图像由 2 名独立的蒙面评分员审查。进行了基于以下特征的定性分析：新生血管复合物 (NVC)、椎间盘新生血管 (NVD)、其他部位新生血管 (NVE)、微动脉瘤 (MA)、视网膜内出血 (IRH)、玻璃体出血 (VH)、视网膜前出血 (PRH) )、纤维化、硬性渗出物 (HE)、视网膜前膜 (ERM)、糖尿病性黄斑水肿 (DME)、缺血和激光斑 (LS)。确定了与 FA 相比的诊断准确性测量。结果 MC检测NVC的灵敏度为95.1%，特异性为 40.0%，阳性预测值 (PPV) 为 92.9%，阴性预测值 (NPV) 为 50.0%。检测 NVD 的敏感性和特异性更高（88.9% 和 76.9%），而 NVE 记录的 PPV 更高（88.9%）。MC在检测IRH、HE、ERM和LS（100%）、MA（98.0%）和纤维化（95.5%）方面高度敏感。VH (100.0%)、DME (100.0%)、PRH (98.1%) 和 LS (89.5%) 的特异性最高。MC 的接受者操作特征分析下面积在 NVD（0.83, 95% 置信区间 (CI), 0.71-0.95, p < 0.001）、IRH (0.89, 95% CI 0.74-1.00, p < 0.001) 方面表现优异, VH (0.81, 95% CI 0.60-1.00, p = 0.005) 和 PRH (0.89, 95% CI 0.68-1.00, p = 0.004) 并且在 LS 检测中表现出色 (0.95, 95% CI 0.87-1.00, p < 0.001 ）。这些结果可能是由于 MC 的对比度和质量，因为绿色波长可以实现更好的区分。结论 MC 可用于评估 PDR 患者并且可以补充无创成像。MC 比 FA 更准确地检测到一些 PDR 特征，例如 NVD、IRH、VH、PRH 和 LS。