Expression of chimeric antigen receptor therapy targets detected by single-cell sequencing of normal cells may contribute to off-tumor toxicity.,Cancer Cell

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Expression of chimeric antigen receptor therapy targets detected by single-cell sequencing of normal cells may contribute to off-tumor toxicity.
Cancer Cell ( IF 48.8 ) Pub Date : 2021-10-21 , DOI: 10.1016/j.ccell.2021.09.016
Ying Jing ₁ , Yuan Liu ₂ , Qiang Li ₂ , Youqiong Ye ₃ , Lixia Diao ₄ , Yun Huang ₅ , Yubin Zhou ₆ , Michael R Green ₇ , Gordon B Mills ₈ , Leng Han ₉

Affiliation

Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.
Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA; Department of Translational Medical Sciences, College of Medicine, Texas A&M University, Houston, TX, USA.
Department of Translational Medical Sciences, College of Medicine, Texas A&M University, Houston, TX, USA; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.
Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.
Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA; Department of Translational Medical Sciences, College of Medicine, Texas A&M University, Houston, TX, USA; Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA.