Infusions of levosimendan delivered in ambulatory/outpatient settings have been shown to improve quality of life and reduce hospitalizations in patients with advanced heart failure. The aim of this study was to evaluate the effects of ambulatory infusion of levosimendan on echocardiographic markers of perfusion, congestion, and cardiovascular efficiency.Thirty patients with diagnosed advanced HF underwent ambulatorial infusion of levosimendan. Standardized transthoracic echocardiography, Doppler examinations, and strain analysis were performed 1 h before and 48 h after completion of ambulatory infusion of 6,25 mg of levosimendan. At 48 h after ambulatory infusion of levosimendan, a significant increase in the stroke volume (37.47 ± 12.38 mL/beat vs 45.47 ± 14.48 mL/beat; p < 0.05) and cardiac output (2.64 ± 0.66 L/min vs 3.26 ± 0.57 L/min; p < 0.05) occurred. Significant post-versus-pre reductions were also recorded in left atrial pressure (27.37 ± 6.62 mmHg vs 22.82 ± 4.17 mmHg; p < 0.01); mean pulmonary artery pressure (27.69 ± 4.64 mmHg vs 23.24 ± 5.32; p < 0.01); and inferior vena cava diameter (23.81 ± 7.63 mm vs 18.53 ± 4.82 mm; p < 0.01) occurred. Significant improvements were noted in the resting cardiac power output (0.46 ± 0,15watt vs 0.53 ± 0.22 watt; p < 0.01) and the resting cardiac power index (0.24 ± 0.08 watt/m2 vs 0.28 ± 0.11 watt/m2; p < 0.01).In outpatients with advanced HF infusion of levosimendan was associated with hemodynamic responses that may contribute to the clinical benefit previously reported in such patients.

中文翻译：

---

左西孟旦对晚期心力衰竭门诊患者的血流动力学影响：超声心动图初步研究。

在门诊/门诊环境中输注左西孟旦已被证明可以改善晚期心力衰竭患者的生活质量并减少住院治疗。本研究的目的是评估动态输注左西孟旦对超声心动图灌注、充血和心血管效率的影响。30 名诊断为晚期 HF 的患者接受了动态输注左西孟旦。在完成动态输注 6.25 mg 左西孟旦前 1 小时和 48 小时进行标准化经胸超声心动图、多普勒检查和应变分析。在动态输注左西孟旦后 48 小时，每搏输出量（37.47 ± 12.38 mL/beat vs 45.47 ± 14.48 mL/beat；p < 0.05）和心输出量（2.64 ± 0.66 L/min vs 3.26 ± 0.57 L）显着增加/分钟；p < 0.05) 发生。左心房压力也有显着的前后降低（27.37 ± 6.62 mmHg vs 22.82 ± 4.17 mmHg；p < 0.01）；平均肺动脉压（27.69 ± 4.64 mmHg vs 23.24 ± 5.32；p < 0.01）；和下腔静脉直径 (23.81 ± 7.63 mm vs 18.53 ± 4.82 mm; p < 0.01)。静息心输出量（0.46 ± 0.15 瓦 vs 0.53 ± 0.22 瓦；p < 0.01）和静息心功率指数（0.24 ± 0.08 瓦/平方米 vs 0.28 ± 0.11 瓦/平方米；p < 0.01）有显着改善). 在晚期 HF 门诊患者中，输注左西孟旦与血流动力学反应有关，这可能有助于先前在此类患者中报告的临床益处。82±4.17 毫米汞柱；p < 0.01); 平均肺动脉压（27.69 ± 4.64 mmHg vs 23.24 ± 5.32；p < 0.01）；和下腔静脉直径 (23.81 ± 7.63 mm vs 18.53 ± 4.82 mm; p < 0.01)。静息心输出量（0.46 ± 0.15 瓦 vs 0.53 ± 0.22 瓦；p < 0.01）和静息心功率指数（0.24 ± 0.08 瓦/平方米 vs 0.28 ± 0.11 瓦/平方米；p < 0.01）有显着改善). 在晚期 HF 门诊患者中，输注左西孟旦与血流动力学反应有关，这可能有助于先前在此类患者中报告的临床益处。82±4.17 毫米汞柱；p < 0.01); 平均肺动脉压（27.69 ± 4.64 mmHg vs 23.24 ± 5.32；p < 0.01）；和下腔静脉直径 (23.81 ± 7.63 mm vs 18.53 ± 4.82 mm; p < 0.01)。静息心输出量（0.46 ± 0.15 瓦 vs 0.53 ± 0.22 瓦；p < 0.01）和静息心功率指数（0.24 ± 0.08 瓦/平方米 vs 0.28 ± 0.11 瓦/平方米；p < 0.01）有显着改善). 在晚期 HF 门诊患者中，输注左西孟旦与血流动力学反应有关，这可能有助于先前在此类患者中报告的临床益处。