Articular cartilage repair is a critical issue in osteoarthritis (OA) treatment. The insulin-like growth factor (IGF) signaling pathway has been implicated in articular cartilage repair. IGF-1 is a member of a family of growth factors that are structurally closely related to pro-insulin and can promote chondrocyte proliferation, enhance matrix production, and inhibit chondrocyte apoptosis. Here, we reviewed the role of IGF-1 in cartilage anabolism and catabolism. Moreover, we discussed the potential role of IGF-1 in OA treatment. Of note, we summarized the recent progress on IGF delivery systems. Optimization of IGF delivery systems will facilitate treatment application in cartilage repair and improve OA treatment efficacy.

中文翻译：

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胰岛素样生长因子-1 在关节软骨修复治疗骨关节炎中的作用

关节软骨修复是骨关节炎 (OA) 治疗中的一个关键问题。胰岛素样生长因子 (IGF) 信号通路与关节软骨修复有关。IGF-1是生长因子家族的一员，在结构上与胰岛素原密切相关，可以促进软骨细胞增殖，增强基质产生，抑制软骨细胞凋亡。在这里，我们回顾了 IGF-1 在软骨合成代谢和分解代谢中的作用。此外，我们讨论了 IGF-1 在 OA 治疗中的潜在作用。值得注意的是，我们总结了 IGF 递送系统的最新进展。IGF 递送系统的优化将促进在软骨修复中的治疗应用并提高 OA 治疗效果。