For people with type 1 diabetes, there are limited evidence-based resources to support self-management when traveling across multiple time zones. Here, we compared glycemic control on insulin degludec versus glargine U100 as the basal insulin for adults using multiple daily injections (MDI) while traveling across multiple time zones.

This randomized crossover pilot study compared insulin degludec versus glargine U100 for adults with type 1 diabetes using MDI insulin during long-haul travel to and from Hawaii to New York. Insulin degludec was administered daily at the same time regardless of time zone, and glargine was administered per travel algorithm. Primary end point was the percentage of time in range (TIR) between 70 and 140 mg/dL during the initial 24 h after each direction of travel. Secondary end points included standard continuous glucose monitoring metrics, jet lag, fatigue, and sleep.

The study enrolled 25 participants (56% women, mean ± SD age of 35 ± 14.5 years, HbA_1c of 7.4 ± 1.2% [57 ± 13.1 mmol/mol], and diabetes duration of 20.6 ± 15 years). There was no significant difference in glycemic outcomes between the two arms of the study, including TIR, hypoglycemia, or hyperglycemia. Neither group achieved >70% TIR 70–180 mg/dL during travel. Jet lag was greater on glargine U100 in eastward travel but not westward. Fatigue was greater after westward travel on glargine. Sleep was not significantly different between basal insulins.

In adults with type 1 diabetes using MDI of insulin and traveling across multiple time zones, glycemic outcomes were similar comparing insulin degludec and glargine U100.

对于 1 型糖尿病患者，在跨多个时区旅行时支持自我管理的循证资源有限。在这里，我们比较了使用德谷胰岛素和甘精 U100 作为成人基础胰岛素的血糖控制情况，在跨多个时区旅行时使用每日多次注射 (MDI)。

这项随机交叉试验研究比较了在往返夏威夷和纽约的长途旅行期间使用 MDI 胰岛素治疗成人 1 型糖尿病患者的德谷胰岛素和甘精胰岛素 U100。无论时区如何，每天在同一时间施用德谷胰岛素，并根据旅行算法施用甘精胰岛素。主要终点是每个行进方向后最初 24 小时内 70 至 140 mg/dL 的时间范围 (TIR) 百分比。次要终点包括标准连续血糖监测指标、时差、疲劳和睡眠。

该研究招募了 25 名参与者（56% 的女性，平均 ± SD 年龄为 35 ± 14.5 岁，HbA _1c为 7.4 ± 1.2% [57 ± 13.1 mmol/mol]，糖尿病病程为 20.6 ± 15 年）。研究的两个组之间的血糖结果没有显着差异，包括 TIR、低血糖或高血糖。在旅行期间，两组均未达到 >70% TIR 70–180 mg/dL。甘精 U100 在东行时时差较大，但不向西。甘精胰岛素西行后，疲劳程度更大。基础胰岛素之间的睡眠没有显着差异。

在使用胰岛素 MDI 并跨越多个时区旅行的 1 型糖尿病成人中，与德谷胰岛素和甘精胰岛素 U100 相比，血糖结果相似。