Background

Metabolomics is a field of omics science that involves the comprehensive measurement of small metabolites in biological samples. It is increasingly being used to study exercise physiology and exercise-associated metabolism. However, the field of exercise metabolomics has not been extensively reviewed or assessed.

Objective

This review on exercise metabolomics has three aims: (1) to provide an introduction to the general workflow and the different metabolomics technologies used to conduct exercise metabolomics studies; (2) to provide a systematic overview of published exercise metabolomics studies and their findings; and (3) to discuss future perspectives in the field of exercise metabolomics.

Methods

We searched electronic databases including Google Scholar, Science Direct, PubMed, Scopus, Web of Science, and the SpringerLink academic journal database between January 1st 2000 and September 30th 2020.

Results

Based on our detailed analysis of the field, exercise metabolomics studies fall into five major categories: (1) exercise nutrition metabolism; (2) exercise metabolism; (3) sport metabolism; (4) clinical exercise metabolism; and (5) metabolome comparisons. Exercise metabolism is the most popular category. The most common biological samples used in exercise metabolomics studies are blood and urine. Only a small minority of exercise metabolomics studies employ targeted or quantitative techniques, while most studies used untargeted metabolomics techniques. In addition, mass spectrometry was the most commonly used platform in exercise metabolomics studies, identified in approximately 54% of all published studies. Our data indicate that biomarkers or biomarker panels were identified in 34% of published exercise metabolomics studies.

Conclusion

Overall, there is an increasing trend towards better designed, more clinical, mass spectrometry-based metabolomics studies involving larger numbers of participants/patients and larger numbers of metabolites being identified.

中文翻译：

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运动和运动中的代谢组学：系统评价

背景

代谢组学是组学科学的一个领域，涉及对生物样品中小代谢物的综合测量。它越来越多地用于研究运动生理学和运动相关的新陈代谢。然而，运动代谢组学领域尚未得到广泛审查或评估。

客观的

这篇关于运动代谢组学的综述有三个目的：（1）介绍一般工作流程和用于进行运动代谢组学研究的不同代谢组学技术；(2) 系统地概述已发表的运动代谢组学研究及其发现；(3) 讨论运动代谢组学领域的未来前景。

方法

我们在 2000 年 1 月 1 日至 2020 年 9 月 30 日期间搜索了电子数据库，包括 Google Scholar、Science Direct、PubMed、Scopus、Web of Science 和 SpringerLink 学术期刊数据库。

结果

根据我们对该领域的详细分析，运动代谢组学研究分为五个主要类别：（1）运动营养代谢；(2) 运动代谢；(3) 运动代谢；(4)临床运动代谢；(5) 代谢组比较。运动代谢是最受欢迎的类别。运动代谢组学研究中最常用的生物样本是血液和尿液。只有少数运动代谢组学研究采用靶向或定量技术，而大多数研究使用非靶向代谢组学技术。此外，质谱是运动代谢组学研究中最常用的平台，在所有已发表的研究中约有 54% 被确定。我们的数据表明，在 34% 的已发表运动代谢组学研究中发现了生物标志物或生物标志物组。

结论

总体而言，越来越多的趋势是设计更好、更临床、基于质谱的代谢组学研究，涉及更多参与者/患者和更多被识别的代谢物。