Cerebral malaria (CM) may cause death or long-term neurological damage in children, and several host genetic risk factors have been reported. Malaria-specific immunoglobulin (Ig) G3 antibodies are crucial to human immune response against malaria. The hinge region of IgG3 exhibits length polymorphism (with long [L], medium [M], and short [S] alleles), which may influence its functionality. We studied IgG3 hinge region length polymorphisms in 136 Ghanaian children with malaria. Using logistic regression models, we found that children with the recessive MM allotype encoding medium IgG3 hinge region length had an increased risk of CM (adjusted odds ratio, 6.67 [95% confidence interval,1.30–34.32]; P=.004) . This has implications for future epidemiological studies on CM.

中文翻译：

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免疫球蛋白 G3 铰链区长度多态性与加纳儿童脑型疟疾的相关性

脑型疟疾 (CM) 可能导致儿童死亡或长期神经系统损伤，并且已经报道了几种宿主遗传风险因素。疟疾特异性免疫球蛋白 (Ig) G3 抗体对人类对疟疾的免疫反应至关重要。IgG3 的铰链区表现出长度多态性（具有长 [L]、中 [M] 和短 [S] 等位基因），这可能会影响其功能。我们研究了 136 名加纳疟疾患儿的 IgG3 铰链区长度多态性。使用逻辑回归模型，我们发现具有编码中等 IgG3 铰链区长度的隐性 MM 同种异体的儿童患 CM 的风险增加（调整优势比，6.67 [95% 置信区间，1.30–34.32]；P=.004）。这对未来的 CM 流行病学研究具有重要意义。