Gut microbiome signatures distinguish type 2 diabetes mellitus from non-alcoholic fatty liver disease,Computational and Structural Biotechnology Journal

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Gut microbiome signatures distinguish type 2 diabetes mellitus from non-alcoholic fatty liver disease
Computational and Structural Biotechnology Journal ( IF 4.4 ) Pub Date : 2021-10-28 , DOI: 10.1016/j.csbj.2021.10.032
Jiyeon Si ₁ , Giljae Lee ₂ , Hyun Ju You _{2,

3} , Sae Kyung Joo ₄ , Dong Hyeon Lee ₄ , Bon Jeong Ku ₅ , Seoyeon Park ₂ , Won Kim ₄ , GwangPyo Ko _{2,

6,

7,

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Affiliation

Non-alcoholic fatty liver disease (NAFLD) is closely associated with type 2 diabetes mellitus (T2D), and these two metabolic diseases demonstrate bidirectional influences. The identification of microbiome profiles that are specific to liver injury or impaired glucose metabolism may assist understanding of the role of the gut microbiota in the relationship between NAFLD and T2D. Here, we studied a biopsy-proven Asian NAFLD cohort (n = 329; 187 participants with NAFLD, 101 with NAFLD and T2D, and 41 with neither) and identified , , and as the principal taxa associated with the severity of NAFLD and T2D, whereas and were specific to NAFLD. In particular, the taxa that were associated with both severe liver pathology and T2D were also significantly associated with markers of diabetes, such as fasting blood glucose and Hb1Ac. Enterotype analysis demonstrated that participants with NAFLD had a significantly higher proportion of and a lower proportion of than a Korean healthy twin cohort (n = 756). However, T2D could not be clearly distinguished from NAFLD. Analysis of an independent T2D cohort (n = 185) permitted us to validate the T2D-specific bacterial signature identified in the NAFLD cohort. Functional inference analysis revealed that endotoxin biosynthesis pathways were significantly enriched in participants with NAFLD and T2D, compared with those with NAFLD alone. These findings may assist with the development of effective therapeutic approaches for metabolic diseases that are associated with specific bacterial signatures.

中文翻译：

肠道微生物组特征可区分 2 型糖尿病和非酒精性脂肪肝

非酒精性脂肪肝（NAFLD）与2型糖尿病（T2D）密切相关，这两种代谢性疾病表现出双向影响。鉴定肝损伤或葡萄糖代谢受损特有的微生物组谱可能有助于了解肠道微生物群在 NAFLD 和 T2D 之间关系中的作用。在这里，我们研究了经活检证实的亚洲 NAFLD 队列（n = 329；187 名参与者患有 NAFLD，101 名参与者患有 NAFLD 和 T2D，41 名参与者两者都没有），并确定、、和作为与 NAFLD 和 T2D 严重程度相关的主要分类群，而和是 NAFLD 特有的。特别是，与严重肝脏病理学和 T2D 相关的分类群也与糖尿病标志物显着相关，例如空腹血糖和 Hb1Ac。肠型分析表明，患有 NAFLD 的参与者的比例显着高于韩国健康双胞胎队列 (n = 756)。然而，T2D 与 NAFLD 无法明确区分。对独立 T2D 队列 (n = 185) 的分析使我们能够验证 NAFLD 队列中确定的 T2D 特异性细菌特征。功能推理分析显示，与单独患有 NAFLD 的参与者相比，患有 NAFLD 和 T2D 的参与者的内毒素生物合成途径显着丰富。这些发现可能有助于开发针对与特定细菌特征相关的代谢疾病的有效治疗方法。

更新日期：2021-10-28

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