Biopsy for molecular risk stratification in uveal melanoma: Yields and molecular characteristics in 119 patients,Clinical & Experimental Ophthalmology

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Biopsy for molecular risk stratification in uveal melanoma: Yields and molecular characteristics in 119 patients
Clinical & Experimental Ophthalmology ( IF 4.9 ) Pub Date : 2021-10-29 , DOI: 10.1111/ceo.14022
Vivian Lin ₁ , In Young Chung ₂ , Elsa Toumi ₃ , Daniel McKay ₂ , John McKenzie ₂ , Penny McKelvie ₄ , Farida Zabih ₅ , Alexandra Hoffmeister ₅ , Dale Wright _{6,

7} , Aphrodite Ntzaferi ₅ , Iris Junhong Wu ₅ , Luke Hesson _{8,

9,

10} , Adrian Fung _{11,

12} , Li-Anne Lim _{13,

14} , Stephen Wong ₃ , Andrew Field ₃ , Peter Earls ₃ , Michael Giblin _{13,

14} , Robert Max Conway _{11,

14} , Svetlana Cherepanoff _{3,

15}

Affiliation

School of Medical Sciences, Faculty of Medicine, UNSW, Sydney, Australia.
Royal Victorian Eye & Ear Hospital, Melbourne, Australia.
Department of Anatomical Pathology and Molecular Oncology, SydPath, St Vincent's Hospital Sydney, Sydney, Australia.
Department of Anatomical Pathology, St Vincent's Hospital Melbourne, Melbourne, Australia.
Department of Cancer Genetics, SydPath, St Vincent's Hospital, Sydney, Australia.
Department of Cytogenetics, Children's Hospital Westmead, Westmead, Australia.
Discipline of Paediatrics & Child Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, Australia.
Prince of Wales Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
Department of Molecular Genetics, Douglass Hanly Moir Pathology, Macquarie Park, Australia.
Westmead and Central Clinical Schools, Specialty of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Department of Ophthalmology, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia.
Chatswood Private Hospital, Chatswood, Australia.
Sydney Eye Hospital, Sydney, Australia.
Faculty of Medicine, St Vincent's Clinical School, Sydney, Australia.

Prognostic cytological and molecular features of uveal melanoma have been well researched and are essential in management. Samples can be obtained in vivo through fine needle aspirate biopsy, vitrector cutter, forceps or post-enucleation for off-site testing. This study aims to examine cytological and chromosome microarray yields of these samples.

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